INT287941

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Context Info
Confidence 0.23
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 2.94
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (FZD5) plasma membrane (FZD5) cytoplasm (FZD5)
signal transducer activity (FZD5)
Anatomy Link Frequency
myeloid cell 1
FZD5 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 25 69.12 Quite High
cINOD 25 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 456 99.92 Very High Very High Very High
Apoptosis 150 99.00 Very High Very High Very High
Adhesions 3 88.40 High High
Death 31 80.28 Quite High
Cancer 123 58.68 Quite High
Toxicity 19 50.00 Quite Low
Disease 42 5.00 Very Low Very Low Very Low
Stress 30 5.00 Very Low Very Low Very Low
Colon Cancer 28 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This classification is not exclusive, for instance, Wnt5a has been shown to activate non-canonical pathways, but when co-expressed with Fzd5, it can induce axis duplication (canonical pathway) [6].
Gene_expression (expressed) of Fzd5
1) Confidence 0.23 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.09 Pain Relevance 0.03
Interestingly, a recent study demonstrated that apoptotic agents imatinib and etoposide could also up-regulate Fzd5 expression in the myeloid cell lines K562 and HL60 [36].
Gene_expression (expression) of Fzd5 in myeloid cell associated with apoptosis
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.33 Pain Relevance 0
To determine the ability of EA to alter LEF-1, cyclin D1, fibronectin and Fzd5 transcript expression, CLL cells from three patients were treated with the drug for 16 h, and then analyzed by real-time PCR.
Gene_expression (expression) of Fzd5 associated with chronic lymphoid leukemia
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.57 Pain Relevance 0
The expression of Fzd5 was also detected in our experiments.
Gene_expression (expression) of Fzd5
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.69 Pain Relevance 0
It is unclear how EA enhances the expression of Fzd5.


Gene_expression (expression) of Fzd5
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.41 Pain Relevance 0
We speculate that the increased expression of Fzd5 might correlate with an apoptotic process.
Gene_expression (expression) of Fzd5 associated with apoptosis
6) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.44 Pain Relevance 0
Interestingly, EA showed dose-dependent enhancement of Fzd5 expression (Figure 3).
Gene_expression (expression) of Fzd5
7) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.41 Pain Relevance 0

General Comments

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