INT287947

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (DVL1) cytoplasm (DVL1) signal transducer activity (DVL1)
cytosol (DVL1) signal transduction (DVL1) plasma membrane (DVL1)
DVL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 2 67.44 Quite High
antagonist 13 59.88 Quite High
cINOD 17 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 129 93.84 High High
Disease 19 83.60 Quite High
Targeted Disruption 3 74.24 Quite High
Familial Adenomatous Polyposis 13 73.28 Quite High
Apoptosis 27 70.80 Quite High
Helminth Infection 1 63.44 Quite High
Diabetes Mellitus 2 56.40 Quite High
Manic Depressive Disorder 3 55.28 Quite High
Hematologic Neoplasms 11 54.80 Quite High
Breast Cancer 32 51.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interrupting the Fzd-Dvl interaction could serve as a powerful tool to dissect the molecular mechanism underlying the Wnt pathways.
Dvl Binding (interaction) of
1) Confidence 0.10 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.47 Pain Relevance 0
, upstream of the degradation complex, consistent with the hypothesis that the relevant target may be membrane-associated, such as Dvl and/or LRP6.
Dvl Binding (associated) of
2) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.22 Pain Relevance 0.06
Upon ligation to their receptors, the cytoplasmic protein disheveled (Dvl) is recruited, phosphorylated and activated.
Dvl Binding (recruited) of
3) Confidence 0.09 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.26 Pain Relevance 0

General Comments

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