INT287954

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.48
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (DVL1) cytoplasm (DVL1) signal transducer activity (DVL1)
cytosol (DVL1) signal transduction (DVL1) plasma membrane (DVL1)
Anatomy Link Frequency
DAN 1
DVL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 25 92.48 High High
cINOD 25 83.76 Quite High
imagery 6 82.60 Quite High
addiction 12 45.16 Quite Low
aspirin 7 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 98.48 Very High Very High Very High
Stress 30 97.96 Very High Very High Very High
Cancer 189 97.68 Very High Very High Very High
Necrosis 2 97.40 Very High Very High Very High
Apoptosis 156 91.88 High High
Chordoma 131 87.20 High High
Chronic Lymphoid Leukemia 456 84.80 Quite High
INFLAMMATION 8 83.36 Quite High
Colon Cancer 28 80.68 Quite High
Disease 51 57.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They include the paired box 7 (PAX7) gene encoding a transcriptional factor expressed in the neural tube which is regulated by notochord specific signals [76], the differentially screening-selected gene aberrant in neuroblastoma (DAN), involved in the negative regulation of cell proliferation [77], the Dishevelled 1 gene (DVL1), a key factor in Wnt signalling expressed in the neural tube [78] and a few genes belonging to the tumour necrosis factor receptor superfamily (TNFRSF-1B, -8, -9, -14), the DNA fragmentation factor (DFF-A and- B) and TP73 [UCSC], all acting in apoptotic pathways.
Gene_expression (expressed) of Dishevelled 1 gene in DAN associated with necrosis, neuroblastoma, cancer and apoptosis
1) Confidence 0.24 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837065 Disease Relevance 1.08 Pain Relevance 0
-catenin pathway by binding to Axin in a disheveled (Dvl) independent manner, while Fzd receptors transduce Wnt signals through Dvl to stabilize ?
Gene_expression (transduce) of Dvl
2) Confidence 0.12 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0 Pain Relevance 0
Treatment with EA reduced Wnt1/LRP6 or Wnt3/LRP6, Dvl, and ?
Gene_expression (/) of Dvl
3) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.31 Pain Relevance 0.16
-catenin pathway, the TOPflash reporter was activated by Wnt1/LRP6 or Wnt3/LRP6, Dvl and ?
Gene_expression (pathway) of Dvl
4) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.18 Pain Relevance 0.21
Treatment with EA reduced Wnt1/LRP6 or Wnt3/LRP6, Dvl, and ?
Gene_expression (/) of Dvl
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.31 Pain Relevance 0.17
The expression plasmids encoding Wnt1, Wnt3, LRP6, Dvl, ?
Gene_expression (expression) of Dvl
6) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.17 Pain Relevance 0
-catenin signaling by EA is mediated by modulation of thiols, or by increased oxidative stress as a result of GST inhibition, cells that had been co-transfected with the TOPflash reporter and the Dvl expression plasmids were treated with EA and various antioxidants (NAC, BHA and PDTC).
Gene_expression (expression) of Dvl associated with stress
7) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.35 Pain Relevance 0
In this system, transfected Dvl (an upstream activator of the Wnt/?
Gene_expression (transfected) of Dvl
8) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.08 Pain Relevance 0.29

General Comments

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