INT287956

Context Info Confidence 0.26 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.38 Pain Relevance 0.04

signal transduction (WNT1) extracellular space (WNT1) extracellular region (WNT1) proteinaceous extracellular matrix (WNT1) plasma membrane (WNT1) cell-cell signaling (WNT1)

WNT1 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 6 71.44 vincristine 1 27.28 cINOD 13 5.00 antagonist 7 5.00 aspirin 7 5.00 Pain 6 5.00 metalloproteinase 6 5.00 Inflammation 5 5.00 corticosteroid 2 5.00 agonist 2 5.00

Disease Link Frequency Relevance Heat Cancer 83 99.78 Targeted Disruption 2 99.06 Recurrence 22 97.44 Disease 139 97.00 Breast Cancer 4 95.76 Apoptosis 21 79.76 Skin Cancer 5 79.52 Disease Progression 4 54.44 Dupuytren's Disease 7 50.00 Carpal Tunnel Syndrome 1 40.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Along these lines, our laboratory has chosen to focus on dysregulation of the Wnt-?

Regulation (dysregulation) of Wnt

1) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2940746 Disease Relevance 1.32 Pain Relevance 0

A transgenic mouse model has recently shown that tumor growth is dependent on Wnt-1 expression [45].

Regulation (dependent) of Wnt-1 associated with targeted disruption and cancer

2) Confidence 0.15 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 1.06 Pain Relevance 0.04

General Comments

This test has worked.