INT288

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 3
Speculated 5
Reported most in Abstract
Documents 88
Total Number 93
Disease Relevance 32.83
Pain Relevance 24.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sct)
Anatomy Link Frequency
plasma 6
pancreas 5
blood 3
bladder 2
smooth muscle 1
Sct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 52 100.00 Very High Very High Very High
Somatostatin 35 100.00 Very High Very High Very High
Bile 30 100.00 Very High Very High Very High
Morphine 16 100.00 Very High Very High Very High
Cholecystokinin 13 100.00 Very High Very High Very High
Neuropeptide 8 100.00 Very High Very High Very High
Raphe magnus 8 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
Dopamine 2 100.00 Very High Very High Very High
Analgesic 13 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 20 100.00 Very High Very High Very High
Urological Neuroanatomy 6 100.00 Very High Very High Very High
Pancreatitis 160 99.84 Very High Very High Very High
Hyperlipidemia 7 99.84 Very High Very High Very High
Nicotine Addiction 9 99.68 Very High Very High Very High
Syndrome 14 99.58 Very High Very High Very High
Stress 360 99.44 Very High Very High Very High
Dyskinesias 8 99.44 Very High Very High Very High
Hepatic Veno-occlusive Disease 60 99.40 Very High Very High Very High
Malignant Neoplastic Disease 8 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The duodenal acidification significantly increased secretin concentration in plasma.
Positive_regulation (increased) of secretin in plasma
1) Confidence 0.70 Published 1994 Journal Pancreas Section Abstract Doc Link 8108364 Disease Relevance 0 Pain Relevance 0
Secretin causes relaxation via activation of secretin receptors located on the smooth muscle and not via any of the related VIP/PACAP receptors.
Positive_regulation (activation) of secretin in smooth muscle
2) Confidence 0.69 Published 2000 Journal Peptides Section Abstract Doc Link 11090923 Disease Relevance 0 Pain Relevance 0.09
Conditioning stimulation of NRM, NRPG, PAG, CP, SCT and DMH strongly inhibited component 2.
Positive_regulation (stimulation) of SCT in SCT associated with raphe magnus and urological neuroanatomy
3) Confidence 0.64 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3795618 Disease Relevance 0.27 Pain Relevance 0.61
Highest levels of parental stress are reported in the period preceding SCT and during the acute phase.
Positive_regulation (preceding) of SCT associated with stress
4) Confidence 0.58 Published 2009 Journal Support Care Cancer Section Abstract Doc Link PMC2775902 Disease Relevance 0.68 Pain Relevance 0
In contrast, CAP from donor rats pretreated with phentolamine, atropine, or hexamethonium did not alter the increase in plasma secretin concentration and pancreatic secretion.
Positive_regulation (increase) of plasma secretin in plasma
5) Confidence 0.57 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653572 Disease Relevance 0 Pain Relevance 0.52
The GI transit rates of nanoparticles having surface poly(N-isopropylacrylamide), poly(vinylamine) and poly(methacrylic acid) chains, which can improve sCT absorption, were slower than that of nanoparticles covered by poly(N-vinylacetamide), which does not enhance sCT absorption at all.
Neg (not) Positive_regulation (enhance) of sCT in poly
6) Confidence 0.50 Published 1999 Journal Int J Pharm Section Abstract Doc Link 10205611 Disease Relevance 0 Pain Relevance 0
The change in blood ionized calcium concentration after oral administration of salmon calcitonin (sCT) with nanoparticles showed that the in vivo enhancement of sCT absorption by radiolabeled nanoparticles was the same as that by non-labeled nanoparticles.
Positive_regulation (enhancement) of sCT in blood
7) Confidence 0.50 Published 1999 Journal Int J Pharm Section Abstract Doc Link 10205611 Disease Relevance 0 Pain Relevance 0
In consideration of previous findings that many other peptides such as substance P, enkephalin, bradykinin, neurotensin and vasoactive intestinal polypeptide cause pressor effects when administered centrally, but produce depressor responses after peripheral administration, the hypotension induced as both central and peripheral effects of secretin is unique and significant.
Positive_regulation (effects) of secretin associated with pressure volume 2 under development, enkephalin, bradykinin and substance p
8) Confidence 0.50 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 3432603 Disease Relevance 0.19 Pain Relevance 0.19
Pancreatic duct dilatation after secretin stimulation in patients with pancreas divisum.
Positive_regulation (stimulation) of secretin in pancreas associated with pain
9) Confidence 0.49 Published 1989 Journal Pancreas Section Title Doc Link 2660134 Disease Relevance 0.38 Pain Relevance 0.26
A second injection of secretin and pancreozymin was given after completion of the standard test.
Positive_regulation (injection) of secretin associated with bile
10) Confidence 0.49 Published 1983 Journal S. Afr. Med. J. Section Abstract Doc Link 6849175 Disease Relevance 0.07 Pain Relevance 0.12
In the current work, we have used inductively coupled plasma mass spectrometry to quantify the metal composition of pancreatic juice collected in response to secretin stimulation in successive patients evaluated for abdominal pain (35 with pancreatic cancer, 30 with chronic pancreatitis, and 35 with normal pancreas).
Positive_regulation (stimulation) of secretin in pancreas associated with abdominal pain, pancreatic cancer and chronic pancreatitis
11) Confidence 0.49 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18086771 Disease Relevance 0.75 Pain Relevance 0.19
[Influence of undernourishment in patients with chronic pancreatitis on amino acid utilization by the pancreas after its stimulation with secretin and cerulein].
Positive_regulation (stimulation) of secretin in pancreas associated with chronic pancreatitis
12) Confidence 0.49 Published 1994 Journal Wiad. Lek. Section Title Doc Link 8030343 Disease Relevance 0.20 Pain Relevance 0.28
The intraductal secretin test: an adjunct to ERCP.
Positive_regulation (intraductal) of secretin
13) Confidence 0.49 Published 1982 Journal Gastrointest. Endosc. Section Title Doc Link 7129052 Disease Relevance 0.43 Pain Relevance 0.09
Is a 15-minute collection of duodenal secretions after secretin stimulation sufficient to diagnose chronic pancreatitis?
Positive_regulation (stimulation) of secretin associated with chronic pancreatitis
14) Confidence 0.49 Published 2004 Journal Pancreas Section Title Doc Link 14707736 Disease Relevance 0.10 Pain Relevance 0.19
[Evaluation of the influence of extrapancreatic factors (undernutrition, cirrhosis) on utilization of amino acids by the pancreas after its stimulation with secretin and cerulein].
Positive_regulation (stimulation) of secretin in pancreas associated with cirrhosis and nutritional deficiencies
15) Confidence 0.49 Published 1993 Journal Wiad. Lek. Section Title Doc Link 7975619 Disease Relevance 0.63 Pain Relevance 0.13
Plasma secretin levels were elevated slightly, while CCK levels remained unchanged.
Positive_regulation (elevated) of secretin in Plasma
16) Confidence 0.48 Published 1998 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 9607398 Disease Relevance 0 Pain Relevance 0.25
We evaluated the behavior of serum cationic trypsinogen (SCT), an enzyme of solely pancreatic origin, in 30 patients with chronic pancreatitis and 25 healthy subjects as a control, after secretin and bombesin stimulation.
Positive_regulation (stimulation) of secretin associated with chronic pancreatitis
17) Confidence 0.47 Published 1987 Journal Pancreas Section Abstract Doc Link 3438309 Disease Relevance 0.34 Pain Relevance 0.27
The aim of this study was to investigate whether IV secretin administration is useful to enhance the delineation of the main pancreatic duct (MPD) and its side branches, and if it provides additional information concerning signal voids and strictures.
Spec (whether) Positive_regulation (enhance) of secretin in MPD
18) Confidence 0.47 Published 1998 Journal Eur Radiol Section Abstract Doc Link 9442122 Disease Relevance 0.25 Pain Relevance 0.16
Assessment of chronic pancreatitis: utility of diffusion-weighted MR imaging with secretin enhancement.
Positive_regulation (enhancement) of secretin associated with imagery and chronic pancreatitis
19) Confidence 0.46 Published 2009 Journal Radiology Section Title Doc Link 19001148 Disease Relevance 0.19 Pain Relevance 0.29
Moreover, the agreement between independent observers increased after the use of secretin.
Positive_regulation (increased) of secretin
20) Confidence 0.46 Published 2007 Journal Rofo Section Abstract Doc Link 17594632 Disease Relevance 0.29 Pain Relevance 0.25

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