INT288007

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.51
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD28, CD40) cytosol (CD28) signal transduction (CD40)
extracellular region (CD40) enzyme binding (CD40) protein complex assembly (CD40)
Anatomy Link Frequency
T cell 1
CD28 (Homo sapiens)
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 11 51.92 Quite High
Inflammation 34 50.00 Quite Low
Multiple sclerosis 1 38.44 Quite Low
Central nervous system 1 34.40 Quite Low
abatacept 1 20.00 Low Low
rheumatoid arthritis 1 8.48 Low Low
corticosteroid 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1 96.92 Very High Very High Very High
Inflammatory Bowel Disease 76 71.60 Quite High
Disease 89 62.88 Quite High
Progressive Multifocal Leukoencephalopathy 3 62.16 Quite High
Adhesions 10 57.28 Quite High
Syndrome 4 50.56 Quite High
Demyelinating Disease 2 38.44 Quite Low
Central Nervous System Disease 1 34.72 Quite Low
Rheumatoid Arthritis 1 8.48 Low Low
INFLAMMATION 27 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include binding of TNF receptor to TNF on the cell surface, CD40 ligand to CD40, and B7 to the costimulation receptor CD28.94 When such costimulatory signals are lacking, the end result is anergy or apoptosis of the T cell rather than activation.
CD28 Binding (ligand) of CD40 in T cell associated with apoptosis
1) Confidence 0.05 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780674 Disease Relevance 0.51 Pain Relevance 0.03

General Comments

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