INT288014

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD40) extracellular region (CD40) plasma membrane (CD40)
enzyme binding (CD40) protein complex assembly (CD40) signal transducer activity (CD40)
CD40 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 34 94.96 High High
cytokine 11 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 94.96 High High
Disease 89 93.40 High High
Inflammatory Bowel Disease 76 50.00 Quite Low
Adhesions 10 5.00 Very Low Very Low Very Low
Colitis 10 5.00 Very Low Very Low Very Low
Nicotine Addiction 6 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Mycobacterial Infection 3 5.00 Very Low Very Low Very Low
Progressive Multifocal Leukoencephalopathy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One hypothesis is that with the loss of binding of muramyl dipeptide to NOD2, there is a compensatory response with failure to inhibit the activation of c-Rel and p50 by binding of peptidoglycan to the toll-like receptor 2.58 This results in the downstream activation of IL-12 and consequent inflammation.
Negative_regulation (inhibit) of Positive_regulation (activation) of p50 associated with inflammation
1) Confidence 0.17 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780674 Disease Relevance 0.63 Pain Relevance 0.09

General Comments

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