INT288019

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Context Info
Confidence 0.00
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.70
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)
Anatomy Link Frequency
neuronal 2
DRG 2
Kcnma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 3 98.08 Very High Very High Very High
nociceptor 15 91.88 High High
agonist 131 91.12 High High
qutenza 90 83.24 Quite High
Pain 10 79.28 Quite High
TRP channel 13 50.00 Quite Low
GABAergic 2 26.08 Quite Low
Inflammation 8 24.08 Low Low
antagonist 8 21.60 Low Low
intrathecal 1 18.12 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 98.08 Very High Very High Very High
Pain 10 79.28 Quite High
Toxicity 38 68.56 Quite High
Targeted Disruption 2 57.72 Quite High
Hypersensitivity 3 24.96 Low Low
INFLAMMATION 8 24.08 Low Low
Neuropathic Pain 2 23.44 Low Low
Depression 8 5.00 Very Low Very Low Very Low
Primary Sclerosing Cholangitis 8 5.00 Very Low Very Low Very Low
Camurati-engelmann Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We compared functional expression levels and secondary effects of channel expression and activation on neuronal survival and signaling.
Regulation (effects) of Gene_expression (expression) of channel in neuronal
1) Confidence 0.00 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2780724 Disease Relevance 0.11 Pain Relevance 0.11
Effects of channel expression on synaptic transmission
Regulation (Effects) of Gene_expression (expression) of channel
2) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780724 Disease Relevance 0.19 Pain Relevance 0.20
Cultured DRG neurones are axotomised, and may better represent a pathological state, culture conditions may influence channel expression, for example TRPA1 (Anand et al., 2008), and responses to thermal stimulation can be dramatically affected by, for example, peripheral vascular responses or thermal conductivity of surrounding tissues.
Spec (may) Regulation (influence) of Gene_expression (expression) of channel in DRG associated with dorsal root ganglion
3) Confidence 0.00 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.39 Pain Relevance 0.32

General Comments

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