INT28802

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 8.80
Pain Relevance 3.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (F2) peptidase activity (F2) extracellular space (F2)
extracellular region (F2) response to stress (F2)
Anatomy Link Frequency
platelets 2
plasma 1
liver 1
F2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 29 99.76 Very High Very High Very High
aspirin 60 98.60 Very High Very High Very High
Angina 18 97.68 Very High Very High Very High
cva 13 96.52 Very High Very High Very High
agonist 3 96.00 Very High Very High Very High
alcohol 3 95.88 Very High Very High Very High
ischemia 2 88.88 High High
Inflammatory marker 2 84.52 Quite High
palliative 1 82.08 Quite High
Pain 4 77.84 Quite High
Disease Link Frequency Relevance Heat
Liver Failure 5 100.00 Very High Very High Very High
Cholangiocarcinoma 2 100.00 Very High Very High Very High
Cirrhosis 2 100.00 Very High Very High Very High
Hypocalcemia 2 100.00 Very High Very High Very High
Metastasis 1 100.00 Very High Very High Very High
Overdose 6 99.70 Very High Very High Very High
Arterial-venous Cerebral Malformations 6 99.66 Very High Very High Very High
Cancer 3 99.40 Very High Very High Very High
Thrombosis 27 99.20 Very High Very High Very High
Cardiovascular Disease 32 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute neurological decline after spontaneous thrombosis of an intracranial AVM is rare, and an association with the prothrombin defect in this patient is likely.
prothrombin Binding (association) of associated with arterial-venous cerebral malformations and thrombosis
1) Confidence 0.47 Published 2007 Journal J. Neurosurg. Section Abstract Doc Link 17330543 Disease Relevance 1.27 Pain Relevance 0.19
No association of plasma prothrombin concentration or the G20210A mutation with incident cardiovascular disease: results from the Cardiovascular Health Study.
prothrombin Neg (No) Binding (association) of in plasma associated with cardiovascular disease
2) Confidence 0.36 Published 2002 Journal Thromb. Haemost. Section Title Doc Link 12008943 Disease Relevance 1.14 Pain Relevance 0.12
This is consistent with the lack of association of prothrombin levels with measures of underlying CVD or procoagulant markers.
prothrombin Binding (association) of associated with cardiovascular disease
3) Confidence 0.36 Published 2002 Journal Thromb. Haemost. Section Abstract Doc Link 12008943 Disease Relevance 1.21 Pain Relevance 0.10
Hepatic function, measured as galactose elimination capacity and prothrombin index, was reduced to about 0.40 times control value.
prothrombin Binding (index) of
4) Confidence 0.36 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3977950 Disease Relevance 0.07 Pain Relevance 0.65
The association between paracetamol overdose and prolonged prothrombin time due to hepatic failure is well recognized.
prothrombin Binding (recognized) of associated with liver failure, paracetamol and overdose
5) Confidence 0.35 Published 2003 Journal Hum Exp Toxicol Section Abstract Doc Link 14686484 Disease Relevance 0.73 Pain Relevance 0.41
Twenty-four hours after acetaminophen the impairment of hepatic function, measured as prothrombin index, and the depletion of hepatic glutathione were prevented.
prothrombin Binding (index) of associated with paracetamol
6) Confidence 0.25 Published 1988 Journal Pharmacol. Toxicol. Section Abstract Doc Link 3413028 Disease Relevance 0.38 Pain Relevance 0.47
The response was not significantly altered in the presence of acute or chronic acetaminophen dosing, as assessed by prothrombin time and factor VII concentrations.
prothrombin Binding (assessed) of associated with paracetamol
7) Confidence 0.20 Published 1999 Journal J Clin Pharmacol Section Abstract Doc Link 9987702 Disease Relevance 0 Pain Relevance 0.57
Univariate analysis showed that female sex, normal performance status, well-differentiated tumor, and curative resection were associated with increased survival; cholangiocarcinoma, nodal metastases, cirrhosis, hypocalcemia, prolonged prothrombin time, and increased serum transaminase and alkaline phosphatase were associated with decreased survival.
prothrombin Binding (associated) of associated with hypocalcemia, cirrhosis, cholangiocarcinoma, cancer and metastasis
8) Confidence 0.15 Published 1989 Journal Surgery Section Abstract Doc Link 2799650 Disease Relevance 1.30 Pain Relevance 0.15
In these children, paracetamol elimination half-life was negatively correlated with serum albumin and positively with prothrombin time, as previously reported in adults with liver disease.
prothrombin Binding (correlated) of in liver
9) Confidence 0.15 Published 1996 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 8739814 Disease Relevance 0.18 Pain Relevance 0
Inhibition of factor VIIa generation and prothrombin activation by treatment with enoxaparin in patients with unstable angina.
prothrombin Binding (generation) of associated with angina
10) Confidence 0.06 Published 2003 Journal Br. J. Haematol. Section Title Doc Link 12588347 Disease Relevance 0.19 Pain Relevance 0.19
Mean levels of prothrombin complex were similar in asymptomatic patients to those in controls, but were significantly decreased during sickle cell crisis (p < 0.05 for factor V and p < 0.0001 for factors II, VII and X).
prothrombin Binding (complex) of associated with sickle cell anemia
11) Confidence 0.03 Published 1996 Journal Hematol Cell Ther Section Abstract Doc Link 8974793 Disease Relevance 0.76 Pain Relevance 0.08
Evidence of efficacy for these alternatives is best described for FEIBA (factor eight bypassing activity), an activated prothrombin complex.
prothrombin Binding (complex) of
12) Confidence 0.03 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994012 Disease Relevance 0.57 Pain Relevance 0
Although only anecdotal reports exist regarding the use of recombinant factor VII and prothrombin complex concentrates (PCC) to rapidly reverse coagulopathy in the setting of life-threatening hemorrhage, the use of these novel agents could have been considered in the scenario described above.21,22



prothrombin Binding (complex) of associated with coagulation disorder and cva
13) Confidence 0.02 Published 2009 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2691517 Disease Relevance 0.46 Pain Relevance 0.05
Platelet activation markers for ex vivo analysis may include a) activation-dependent epitopes of the membrane glycoprotein (GP) IIb/IIIa (CD41a) receptor, as demonstrated by the binding of activation-specific monoclonal antibodies (MoAbs) PAC1, anti-LIBS1 and anti-RIBS); b) the expression of P-selectin (CD62p), the alpha-granule GP translocated to the platelet surface following release reaction; and c) platelet procoagulant activity, as demonstrated by the binding of i) annexin V protein to the prothrombinase-complex (prothrombin, activated factor X (Xa) and V (Va)) binding sites on the surface of activated platelets, and of ii) MoAbs against activated coagulation factors V and X bound to the surface of activated platelets.
prothrombin Binding (binding) of in Platelet
14) Confidence 0.02 Published 2004 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 15471223 Disease Relevance 0.33 Pain Relevance 0.10
Second, activated platelets bind prothrombin and thrombin, shielding them from inactivation by heparin [39,40].
prothrombin Binding (bind) of in platelets
15) Confidence 0.01 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59637 Disease Relevance 0.20 Pain Relevance 0.38

General Comments

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