INT288046

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
neurons 2


Pain Term Frequency Confidence Heat
Inflammatory stimuli 1 79.04 Quite High
Inflammation 19 78.64 Quite High
cytokine 23 63.60 Quite High
Spinal cord 2 59.68 Quite High
aspirin 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Infection 63 99.28 Very High Very High Very High
Influenza Virus Infection 67 92.60 High High
INFLAMMATION 20 78.72 Quite High
Neurodegenerative Disease 2 62.64 Quite High
Multiple Sclerosis 4 60.88 Quite High
Spinal Cord Injury 2 59.96 Quite High
Viral Infection 6 56.08 Quite High
Viral Meningitis 3 50.00 Quite Low
Autoimmune Disease 1 47.56 Quite Low
Cytomegalovirus Infection 1 33.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infection in neurons or other CNS cell types leads to rapid local production of type I Interferons (IFN) in a bid to curtail virus spread and replication.
Positive_regulation (leads) of Gene_expression (production) of type I Interferons in neurons associated with infection
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.75 Pain Relevance 0.15
Once TLR7 recognizes ssRNA, the adaptor protein myeloid differentiation primary response protein 88 (MyD88), via down-stream signal activation of transcription factors, results in the production of type I Interferons (IFNs) and inhibition of viral replication.
Positive_regulation (results) of Gene_expression (production) of type I Interferons
2) Confidence 0.45 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.15 Pain Relevance 0.03

General Comments

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