INT288058

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 2.13
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 12
B cells 8
Cd80 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 47 91.44 High High
cytokine 62 90.52 High High
Arthritis 33 82.12 Quite High
Deep tissue 2 81.44 Quite High
Potency 1 67.36 Quite High
chemokine 8 67.20 Quite High
tolerance 8 50.00 Quite Low
Inflammation 21 46.32 Quite Low
rheumatoid arthritis 16 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 96 98.70 Very High Very High Very High
Cancer 180 97.10 Very High Very High Very High
Neurodegenerative Disease 2 95.48 Very High Very High Very High
Targeted Disruption 8 87.24 High High
Experimental Arthritis 20 82.12 Quite High
Disease Progression 2 81.84 Quite High
Apoptosis 30 79.80 Quite High
Fever 4 77.12 Quite High
Gastritis 7 50.00 Quite Low
Viral Meningitis 3 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More importantly, 55°C-HIFU-treated tumor cells showed much more potent immunostimulatory activities than 80°C-HIFU-treated ones, both in the induction of IL-12p70 production and in the upregulation of CD80 and CD86 expression.
Regulation (upregulation) of Gene_expression (expression) of CD80 in CD86 associated with cancer
1) Confidence 0.35 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.85 Pain Relevance 0.07
Specifically, the expression levels of CD40, CD80, CD86 and MHC II were evaluated in unlabeled, SPIO-loaded and PMA-activated B cells via flow cytometry, Fig. 1D.
Regulation (evaluated) of Gene_expression (expression) of CD80 in B cells
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.09 Pain Relevance 0.13
Contrary to what we expected, vitamin C applied at non-cytotoxic concentrations did not affect either the proliferation of B cells or the surface expression of activation markers, CD80 and CD86 (Fig. 4, 5).
Neg (not) Regulation (affect) of Gene_expression (expression) of CD80 in CD86
3) Confidence 0.32 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Pretreatment with vitamin C in the safe range did not affect either proliferation of cultured B cells or the expression of CD80 and CD86 in those cells.
Regulation (proliferation) of Gene_expression (expression) of CD80 in CD86
4) Confidence 0.32 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998772 Disease Relevance 0.08 Pain Relevance 0
To summarize, vitamin C did not affect proliferation, or CD80 and CD86 expression in cultures of activated B cells.
Neg (not) Regulation (affect) of Gene_expression (expression) of CD80 in B cells
5) Confidence 0.32 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0.11
To summarize, vitamin C did not affect proliferation, or CD80 and CD86 expression in cultures of activated B cells.
Regulation (proliferation) of Gene_expression (expression) of CD80 in B cells
6) Confidence 0.32 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0.08
Vitamin C did not affect the expressions of CD80 and CD86 in activated B cells
Neg (not) Regulation (affect) of Gene_expression (expressions) of CD80 in B cells
7) Confidence 0.32 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0 Pain Relevance 0
Pretreatment with vitamin C in the safe range did not affect either proliferation of cultured B cells or the expression of CD80 and CD86 in those cells.
Neg (not) Regulation (affect) of Gene_expression (expression) of CD80 in CD86
8) Confidence 0.32 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998772 Disease Relevance 0.08 Pain Relevance 0
Silencing was specific in that CD 40 siRNA did not change gene expression of CD80 in DCs (Figure 1C).
Neg (not) Regulation (change) of Gene_expression (expression) of CD80
9) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.24 Pain Relevance 0.07
In an experimental model of JEV infection, we have observed that the Nestin positive cells express and up-regulate the expression of costimulatory molecules, CD40, CD80 and CD86 on their surface.
Regulation (regulate) of Gene_expression (expression) of CD80 in CD86 associated with infection
10) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780913 Disease Relevance 0.49 Pain Relevance 0.09
was used as a positive control to enhance the surface expression of MHC class I and II molecules, CD80 and CD86.
Regulation (control) of Gene_expression (expression) of CD80 in CD86
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.30 Pain Relevance 0

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