INT288080

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Context Info
Confidence 0.04
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.42
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 86 99.04 Very High Very High Very High
antidepressant 3 72.72 Quite High
Hippocampus 17 64.64 Quite High
imagery 10 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Pyramidal cell 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 3 100.00 Very High Very High Very High
Cv Unclassified Under Development 30 99.04 Very High Very High Very High
Disease 102 98.98 Very High Very High Very High
Stress 26 93.08 High High
Cognitive Disorder 33 88.96 High High
Cv General 4 Under Development 55 86.72 High High
Dysphagia 6 86.36 High High
Dystonia 6 75.88 Quite High
Tremor 6 75.36 Quite High
Sleep Disorders 6 73.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include neurosteroids and cholesterol-binding agents, which have been shown to delay the progression of disease in animal models of NP-C.23–25 Direct or indirect overexpression of the GTPase, Rab 9, has been shown to reverse the NP-C phenotype in tissue culture26,27 and reduce stored lipids and prolong lifespan in a mouse model of NP-C.28 Recently, curcumin has been suggested to have beneficial effects on intracellular calcium homeostasis and lipid metabolism in NPC1-mutant mice.29 However, data from clinical studies are required to assess the possible role of these compounds in NP-C therapy.
Regulation (effects) of Gene_expression (overexpression) of GTPase associated with lifespan and disease
1) Confidence 0.04 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781062 Disease Relevance 0.74 Pain Relevance 0.04
These include neurosteroids and cholesterol-binding agents, which have been shown to delay the progression of disease in animal models of NP-C.23–25 Direct or indirect overexpression of the GTPase, Rab 9, has been shown to reverse the NP-C phenotype in tissue culture26,27 and reduce stored lipids and prolong lifespan in a mouse model of NP-C.28 Recently, curcumin has been suggested to have beneficial effects on intracellular calcium homeostasis and lipid metabolism in NPC1-mutant mice.29 However, data from clinical studies are required to assess the possible role of these compounds in NP-C therapy.
Spec (possible) Regulation (role) of Gene_expression (overexpression) of GTPase associated with lifespan and disease
2) Confidence 0.04 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781062 Disease Relevance 0.87 Pain Relevance 0.04
These include neurosteroids and cholesterol-binding agents, which have been shown to delay the progression of disease in animal models of NP-C.23–25 Direct or indirect overexpression of the GTPase, Rab 9, has been shown to reverse the NP-C phenotype in tissue culture26,27 and reduce stored lipids and prolong lifespan in a mouse model of NP-C.28 Recently, curcumin has been suggested to have beneficial effects on intracellular calcium homeostasis and lipid metabolism in NPC1-mutant mice.29 However, data from clinical studies are required to assess the possible role of these compounds in NP-C therapy.
Regulation (reverse) of Gene_expression (overexpression) of GTPase associated with lifespan and disease
3) Confidence 0.04 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781062 Disease Relevance 0.74 Pain Relevance 0.04
Functional outcome of Rac GTPase inhibition on learning and spatial memory in the hippocampal CA1 region
Regulation (outcome) of Gene_expression (inhibition) of Rac GTPase
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.07 Pain Relevance 0.30

General Comments

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