INT288084

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Rab9) plasma membrane (Rab9) GTPase activity (Rab9)
lysosome (Rab9)
Anatomy Link Frequency
brain 1
Rab9 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 6 88.00 High High
antidepressant 1 72.72 Quite High
cINOD 1 54.48 Quite High
depression 1 5.00 Very Low Very Low Very Low
antiepileptic Drug 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 99.10 Very High Very High Very High
Disease 143 98.98 Very High Very High Very High
Lifespan 7 95.72 Very High Very High Very High
Dysphagia 8 86.36 High High
Congenital Anomalies 12 79.20 Quite High
Dystonia 13 75.88 Quite High
Tremor 5 75.36 Quite High
Sleep Disorders 15 73.80 Quite High
Convulsion 10 72.04 Quite High
INFLAMMATION 1 54.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Various transgenic mice have been generated, such as mice over expressing Rab9, a protein involved in intracellular trafficking [131-133], or mice expressing NPC1 only in one particular brain cell type [134].
Gene_expression (expressing) of Rab9 in brain associated with targeted disruption
1) Confidence 0.27 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0.31 Pain Relevance 0.10
These include neurosteroids and cholesterol-binding agents, which have been shown to delay the progression of disease in animal models of NP-C.23–25 Direct or indirect overexpression of the GTPase, Rab 9, has been shown to reverse the NP-C phenotype in tissue culture26,27 and reduce stored lipids and prolong lifespan in a mouse model of NP-C.28 Recently, curcumin has been suggested to have beneficial effects on intracellular calcium homeostasis and lipid metabolism in NPC1-mutant mice.29 However, data from clinical studies are required to assess the possible role of these compounds in NP-C therapy.
Gene_expression (overexpression) of Rab 9 associated with lifespan and disease
2) Confidence 0.13 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2781062 Disease Relevance 0.74 Pain Relevance 0.04

General Comments

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