INT28809

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Context Info
Confidence 0.53
First Reported 1989
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.21
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CXCL1) signal transduction (CXCL1) extracellular space (CXCL1)
extracellular region (CXCL1) intracellular (CXCL1)
Anatomy Link Frequency
pancreas 1
CXCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7 99.84 Very High Very High Very High
Inflammation 54 99.66 Very High Very High Very High
dexamethasone 2 97.08 Very High Very High Very High
Chronic pancreatitis 2 94.80 High High
corticosteroid 3 92.20 High High
addiction 1 55.28 Quite High
cINOD 2 51.44 Quite High
chemokine 7 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenoma 36 99.84 Very High Very High Very High
INFLAMMATION 55 99.66 Very High Very High Very High
Pancreatitis 7 98.36 Very High Very High Very High
Pancreatic Cancer 4 96.44 Very High Very High Very High
Cleidocranial Dysplasia 18 94.32 High High
Malignant Neoplastic Disease 19 93.28 High High
Colon Cancer 3 89.32 High High
Disease 9 77.40 Quite High
Adhesions 1 57.68 Quite High
Colorectal Cancer 16 44.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several inflammatory cytokine genes (CXCL1, CXCL2, CXCL3, CCL20, IL8, CCL23, CCL19, CCL21, CCL5) are dysregulated in adenomas.
Regulation (dysregulated) of CXCL1 associated with adenoma, inflammation and cytokine
1) Confidence 0.53 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017541 Disease Relevance 1.92 Pain Relevance 0.48
Results indicate a high diagnostic value of determination FSP, trypsin and C-peptide in patients with acute pancreatitis and chronic recurring pancreatitis at the stage of exacerbation, trypsin and C-peptide in patients with chronic pancreatitis associated with severe exocrine insufficiency of the pancreas, KA 19-9 in patients with cancer of the pancreas.
Regulation (value) of FSP in pancreas associated with pancreatic cancer, pancreatitis and chronic pancreatitis
2) Confidence 0.26 Published 1989 Journal Vrach Delo Section Abstract Doc Link 2800494 Disease Relevance 0.90 Pain Relevance 0.19
Furthermore, this inhibition was either as effective, or for ICAM-1, MCP-1, GROalpha, and NAP-2, more effective, than a maximally effective concentration of dexamethasone.
Regulation (effective) of GROalpha associated with dexamethasone
3) Confidence 0.07 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 0.39 Pain Relevance 0.41

General Comments

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