INT288099

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.04
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP, App) extracellular matrix organization (APP, App) DNA binding (APP, App)
cytoplasm (APP, App) cell adhesion (APP, App) plasma membrane (APP, App)
Anatomy Link Frequency
plaques 1
APP (Homo sapiens)
App (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 1 100.00 Very High Very High Very High
Inflammation 24 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 19 100.00 Very High Very High Very High
Amyloid Plaque 8 93.32 High High
Disease 52 86.64 High High
Neurodegenerative Disease 2 67.12 Quite High
Toxicity 5 66.40 Quite High
INFLAMMATION 25 5.00 Very Low Very Low Very Low
Dementia 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A Japanese study showed that using fluorescence spectroscopic analysis with thioflavin T and electron microscopic studies, curcumin destabilizes the fA-beta(1-40) and fA-beta(1-42) as well as their extension.[27] Curcumin-derived isoxazoles and pyrazoles bind to the amyloid beta peptide (Abeta) and inhibit amyloid precursor protein (APP) metabolism.[28] Curcumin given to APPswe/PS1dE9 mice for 7 days crosses the blood-brain barrier as demonstrated by muliti-photon microscopy and reduces the existing senile plaques.[29] In another study, curcumin has been shown to increase the phagocytosis of amyloid-beta, effectively clearing them from the brains of patients with AD.[30]

Metal Chelation

amyloid beta peptide Binding (bind) of APP in plaques associated with alzheimer's dementia, disease, amyloid plaque and abeta
1) Confidence 0.01 Published 2008 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2781139 Disease Relevance 1.04 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox