INT28815

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Context Info
Confidence 0.65
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 11.02
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B cells 3
memory B cell 2
immature B cells 2
liver 1
erythrocyte 1
Ighd (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 3 99.98 Very High Very High Very High
Multiple sclerosis 10 99.44 Very High Very High Very High
Crohn's disease 3 99.28 Very High Very High Very High
Inflammation 86 96.38 Very High Very High Very High
Pain 7 94.84 High High
headache 4 91.76 High High
abdominal pain 5 91.36 High High
cytokine 156 87.60 High High
rheumatoid arthritis 116 76.16 Quite High
Inflammatory response 6 75.20 Quite High
Disease Link Frequency Relevance Heat
Pancytopenia 1 99.68 Very High Very High Very High
Demyelinating Disease 10 99.44 Very High Very High Very High
Familial Mediterranean Fever 15 99.42 Very High Very High Very High
Disease 104 99.28 Very High Very High Very High
Syndrome 126 96.84 Very High Very High Very High
INFLAMMATION 93 96.38 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 66 95.46 Very High Very High Very High
Mevalonate Kinase Deficiency 38 95.32 Very High Very High Very High
Inflammatory Bowel Disease 3 95.32 Very High Very High Very High
Infection 384 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-secretase LRP cleavage and release of the LRP-ICD.
Gene_expression (cleavage) of ICD in cleavage
1) Confidence 0.65 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.24 Pain Relevance 0.05
The levels of IgD were measured in a series of patients with CD to evaluate the specificity of this assay in the differential diagnosis between the two conditions.
Gene_expression (levels) of IgD associated with crohn's disease
2) Confidence 0.58 Published 2006 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 16635911 Disease Relevance 1.54 Pain Relevance 0.42
Because the developing B220low IgM-IgD- cells and IgM+IgD- immature B cells are so severely affected in Lmna-/- mice, it is likely that these B220high IgM+IgD+ mature B cells reached maturity before these mice experienced the precipitous decline in B cell development.
Gene_expression (affected) of IgD in immature B cells
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.05 Pain Relevance 0
M.1- and WT virus–infected mice, CD19+ lung and splenic B cells were analyzed for markers of isotype-class switching (IgD?)
Spec (analyzed) Gene_expression (lung) of IgD in B cells
4) Confidence 0.45 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.17 Pain Relevance 0.11
Because the developing B220low IgM-IgD- cells and IgM+IgD- immature B cells are so severely affected in Lmna-/- mice, it is likely that these B220high IgM+IgD+ mature B cells reached maturity before these mice experienced the precipitous decline in B cell development.
Gene_expression (affected) of IgD in immature B cells
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.05 Pain Relevance 0
A study made of CD19+ PBL B cells in relation to their expression of IgM and IgD detected several sub-populations of circulating B cells (see Figure S4 for gating strategy).
Gene_expression (expression) of IgD in B cells
6) Confidence 0.32 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2919407 Disease Relevance 0.63 Pain Relevance 0
Intrathecal synthesis of IgG, IgA, IgM and IgD in untreated multiple sclerosis and controls.
Gene_expression (synthesis) of IgD associated with multiple sclerosis and intrathecal
7) Confidence 0.27 Published 1989 Journal Acta Neurol. Scand. Section Title Doc Link 2801020 Disease Relevance 0.92 Pain Relevance 0.60
Although the exact mechanism of action of AID is currently unclear [18], CSR occurs via excision of switch circles following the introduction of double strand breaks in the Ig switch regions of DNA, with the subsequent substitution of IgM and IgD with IgG, IgE, or IgA [19], and hence production of antibodies with specific effector functions.
Gene_expression (production) of IgD
8) Confidence 0.26 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621263 Disease Relevance 0.06 Pain Relevance 0.03
Laboratory findings in TRAPS are in accordance with a typical inflammatory episode: high levels of C-reactive protein, neutrophilia, moderate complement activation, raised mean erythrocyte sedimentation rate, and, in some cases, marginally raised IgA and IgD levels [16,17,20-22].
Gene_expression (levels) of IgD in erythrocyte associated with inflammation and tumor necrosis factor receptor-associated periodic syndrome
9) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 2.54 Pain Relevance 0.57
She was found to have pancytopenia and high serum levels of LDH and IgD.
Gene_expression (levels) of IgD associated with pancytopenia
10) Confidence 0.21 Published 2004 Journal Rinsho Ketsueki Section Abstract Doc Link 15553049 Disease Relevance 0.36 Pain Relevance 0.16
However, processing events removing the spacer region might generate a more promiscuous and destructive activity capable of disaggregating aggrecan–hyaluronan complexes through IGD proteolysis, resulting in the loss of aggrecan from the tissue.
Gene_expression (proteolysis) of IGD
11) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.16 Pain Relevance 0.03
Increased levels of immunoglobulin D (IgD) and, in most patients of immunoglobulin A (IgA), in combination with enhanced excretion of mevalonic acid provide strong evidence for HIDS.
Gene_expression (levels) of IgD associated with syndrome
12) Confidence 0.12 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1475558 Disease Relevance 2.20 Pain Relevance 0
In the primary response, characterized by expression of membrane IgM and IgD, VDJ (heavy chain) and VJ (light chain) recombination occurs in fetal tissue (liver and bone marrow).
Gene_expression (expression) of IgD in bone marrow
13) Confidence 0.09 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0 Pain Relevance 0.11
Together, these data provide strong evidence that M2 expression leads to B cell activation and differentiation similar to a functional activated, pre-plasma memory B cell phenotype, namely CD19+, sIgG+, sIgD?
Gene_expression (phenotype) of sIgD in memory B cell
14) Confidence 0.09 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.05 Pain Relevance 0.05
Together, these data provide strong evidence that M2 expression leads to B cell activation and differentiation similar to a functional activated, pre-plasma memory B cell phenotype, namely CD19+, sIgG+, sIgD?
Gene_expression (sIgG+) of sIgD in memory B cell
15) Confidence 0.09 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.05 Pain Relevance 0.05
At four days post-transduction, B cells expressing M2 were CD19+, CD25high, GL7high, B220low, I-Ab low, surface IgD?
Gene_expression (transduction) of surface IgD in B cells
16) Confidence 0.09 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.16 Pain Relevance 0
Studies have measured immunoglobulin (Ig) levels in the sera of FMF patients and found elevated levels of IgA, IgM, IgG, and IgD in 23%, 13%, 17% and 13%, respectively.
Gene_expression (levels) of IgD associated with familial mediterranean fever
17) Confidence 0.06 Published 2004 Journal Sante Section Abstract Doc Link 15745878 Disease Relevance 1.53 Pain Relevance 0.18
M2 protein expression in primary B cells also led to upregulated surface expression of the high affinity IL-2 receptor (CD25) and the activation marker GL7, along with down-regulated surface expression of B220, MHC II, and sIgD.
Gene_expression (ace expres) of sIgD in GL7
18) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2270344 Disease Relevance 0.30 Pain Relevance 0
In the primary response, characterized by expression of membrane IgM and IgD, VDJ (heavy chain) and VJ (light chain) recombination occurs in fetal tissue (liver and bone marrow).
Gene_expression (expression) of IgD in liver
19) Confidence 0.03 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0 Pain Relevance 0.11

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