INT288158

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Context Info
Confidence 0.30
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.73
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd44) Golgi apparatus (Cd44) plasma membrane (Cd44)
nucleus (Cd44) protein complex (Cd44) cytoplasm (Cd44)
Anatomy Link Frequency
apoptotic cells 2
lymphocyte 1
T cells 1
Cd44 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 17 97.56 Very High Very High Very High
Spinal cord 4 96.32 Very High Very High Very High
cytokine 32 84.64 Quite High
Multiple sclerosis 34 81.76 Quite High
Inflammatory response 2 75.32 Quite High
Inflammation 20 61.08 Quite High
rheumatoid arthritis 8 47.76 Quite Low
cINOD 4 26.16 Quite Low
dexamethasone 44 22.68 Low Low
corticosteroid 2 17.84 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 100 99.96 Very High Very High Very High
Breast Cancer 5 99.48 Very High Very High Very High
Skin Cancer 20 98.92 Very High Very High Very High
Cancer 214 98.80 Very High Very High Very High
Central Nervous System Disease 12 97.56 Very High Very High Very High
Adhesions 8 95.16 Very High Very High Very High
Multiple Sclerosis 100 92.64 High High
Brain Tumor 60 87.28 High High
Recurrence 6 83.32 Quite High
Rhinitis 2 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, splenic T cells showed significantly increased apoptosis, reduced surface levels of LFA-1, CD44 and VLA-4 and impaired lymphocyte migration to the inflamed CNS [19].
Negative_regulation (reduced) of in T cells Gene_expression (levels) of CD44 in lymphocyte associated with central nervous system and apoptosis
1) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 1.61 Pain Relevance 0.38
While the percentage of apoptotic cells was again unaltered, surface expression levels of LFA-1 and CD44 were reduced on Th cells from CpdA treated mice in a dose-dependent manner (Fig. 6B).
Negative_regulation (reduced) of Gene_expression (expression) of CD44 in apoptotic cells associated with apoptosis
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.95 Pain Relevance 0.17
Overexpression of CD44 on the other hand blocked p53-dependent apoptosis, leading to expansion of tumor-initiating cells [93].
Negative_regulation (blocked) of Gene_expression (Overexpression) of CD44 associated with cancer and apoptosis
3) Confidence 0.20 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.02 Pain Relevance 0.04
USC-HN1 cells demonstrate strong, uniform nuclear p53 and Rb expression, as well as positive expression of keratin, E-cadherin, EGFr, and CD44 in situ consistent with HNSCC as well as the original tumor biopsy [4,7,13,19].
Negative_regulation (demonstrate) of Gene_expression (expression) of CD44 associated with cancer
4) Confidence 0.17 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.14 Pain Relevance 0
There is decreased staining of E-cadherin and CD44 in situ compared with cultured cells.
Negative_regulation (decreased) of Gene_expression (staining) of CD44
5) Confidence 0.17 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.00 Pain Relevance 0

General Comments

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