INT288184

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.73
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr1) plasma membrane (Tlr1) intracellular (Tlr1)
Anatomy Link Frequency
internal 1
T cells 1
Tlr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 178 97.52 Very High Very High Very High
cytokine 101 58.72 Quite High
ischemia 14 58.44 Quite High
agonist 9 36.24 Quite Low
chemokine 11 16.72 Low Low
Inflammatory response 48 5.00 Very Low Very Low Very Low
tolerance 14 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lyme Disease 13 99.38 Very High Very High Very High
Apoptosis 9 99.16 Very High Very High Very High
INFLAMMATION 206 97.52 Very High Very High Very High
Aging 64 96.12 Very High Very High Very High
Francisella Infection 28 95.92 Very High Very High Very High
American Trypanosomiasis 3 94.52 High High
Hemorrhagic Shock 96 92.56 High High
Bacterial Respiratory Disease 4 86.04 High High
Infection 148 82.60 Quite High
Sprains And Strains 91 74.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B pathway, such as STAT1 and TLR1; cell proliferation/apoptosis, such as IER3; EHF; LRPAP1 and inflammation such as CCL7; CXCL16; B2M; IL7R and LGALS3 were among the genes whose transcripts were increased in the context of both in vivo aging and in vitro senescence.
TLR1 Binding (as) of associated with aging, inflammation and apoptosis
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.69 Pain Relevance 0.05
T cells, express TLR1, TLR2 and dectin-1, respond to IL-23 and recognize various pathogens [42].
TLR1 Binding (recognize) of in T cells
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887844 Disease Relevance 0.84 Pain Relevance 0
Briefly, TLR2, which works with TLR1 or TLR6, recognizes bacterial components, such as lipopeptide and lipoprotein of gram-positive bacteria; specifically, the heterodimer TLR1/2 which can recognize triacyl lipopeptide, while TLR2/6 recognizes diacyl lipopeptide.TLR7 is documented to recognize RNA, while TLR9-DNA, both microbial and self [89, 90].


TLR1 Binding (recognize) of
3) Confidence 0.24 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.24 Pain Relevance 0.06
A second structure shows TLR1-TLR2 heterodimers bound to the hydrophobic Pam3CSK4 lipopeptide that fits in an internal hydrophobic pocket [51].
TLR1 Binding (bound) of in internal
4) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0 Pain Relevance 0
TLR2 recognizes its ligands by forming a heterodimer with either TLR1 or TLR6.
TLR1 Binding (recognizes) of
5) Confidence 0.14 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.81 Pain Relevance 0.06
The resulting TLR1/TLR2 and TLR6/TLR2 complexes recognize distinct ligands, triacyl and diacyl lipoproteins, respectively.
TLR1 Binding (recognize) of
6) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.79 Pain Relevance 0.05
TLR2 recognizes its ligands by forming a heterodimer with either TLR1 or TLR6.
TLR1 Binding (heterodimer) of
7) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913855 Disease Relevance 0.80 Pain Relevance 0.06
The principal proinflammatory DAMPs of the spirochetal pathogen Borrelia burgdorferi, the causative agent of Lyme disease, are triacylated lipoproteins recognized by heterodimers of TLR2 and TLR1 [1].
TLR1 Binding (recognized) of associated with lyme disease
8) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.57 Pain Relevance 0.13

General Comments

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