INT288191

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.27
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Pik3r1) protein complex (Pik3r1) cytoplasm (Pik3r1)
cytosol (Pik3r1) signal transduction (Pik3r1) nucleus (Pik3r1)
Anatomy Link Frequency
fat cells 3
muscle 1
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 6 99.16 Very High Very High Very High
Inflammatory response 39 93.52 High High
Inflammation 81 84.72 Quite High
tolerance 78 83.68 Quite High
cytokine 114 70.16 Quite High
antagonist 31 5.00 Very Low Very Low Very Low
Somatostatin 8 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 98 100.00 Very High Very High Very High
INFLAMMATION 123 93.16 High High
Lyme Disease 39 91.80 High High
Syndrome 3 49.28 Quite Low
Hyperinsulinism 20 39.96 Quite Low
Diabetes Mellitus 60 39.12 Quite Low
Disease 24 25.00 Low Low
Pressure And Volume Under Development 12 16.92 Low Low
Targeted Disruption 111 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Positive_regulation (stimulated) of Localization (translocation) of PI3K in fat cells associated with kinase c and obesity
1) Confidence 0.15 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10
CD14 deficiency results in increased localization of PI3K to lipid rafts, hyperphosphorylation of AKT, and reduced activation of p38.
Positive_regulation (increased) of Localization (localization) of PI3K
2) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2781632 Disease Relevance 0.47 Pain Relevance 0.31
CD14 deficiency results in increased localization of PI3K to lipid rafts, hyperphosphorylation of AKT, and reduced activation of p38.
Positive_regulation (results) of Localization (localization) of PI3K
3) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2781632 Disease Relevance 0.47 Pain Relevance 0.31
We found that following activation by B. burgdorferi, significantly more PI3K is recruited to the lipid rafts of M?
Positive_regulation (following) of Localization (recruited) of PI3K
4) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0 Pain Relevance 0
Two important targets of PI3K in muscle and fat cells that have been shown to have a role in insulin-stimulated GLUT-4 translocation are the AKT and the protein kinase C (PKC).
Positive_regulation (stimulated) of in muscle Localization (translocation) of PI3K in fat cells associated with kinase c and obesity
5) Confidence 0.05 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.16 Pain Relevance 0.10

General Comments

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