INT288216

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Context Info
Confidence 0.34
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.94
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Sh2b1) cytoplasm (Sh2b1) signal transducer activity (Sh2b1)
Anatomy Link Frequency
axial skeleton 1
Sh2b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 33.20 Quite Low
Central nervous system 15 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Mechanotransduction 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Scoliosis 314 97.36 Very High Very High Very High
Obesity 152 84.52 Quite High
Osteoporosis 13 25.00 Low Low
Intervertebral Disk Degeneration 4 25.00 Low Low
Stress 16 5.00 Very Low Very Low Very Low
Syndrome 16 5.00 Very Low Very Low Very Low
Congenital Anomalies 14 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Handedness 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The autonomic component of this double neuro-osseous theory for AIS pathogenesis in girls involves selectively increased sensitivity of the hypothalamus to circulating leptin (genetically-determined up-regulation possibly involving inhibitory or sensitizing intracellular molecules, such as SOC3, PTP-1B and SH2B1 respectively), with asymmetry as an adverse response (hormesis); this asymmetry is routed bilaterally via the sympathetic nervous system to the growing axial skeleton where it may initiate the scoliosis deformity (leptin-hypothalamic-sympathetic nervous system concept = LHS concept).
Positive_regulation (up-regulation) of SH2B1 in axial skeleton associated with scoliosis
1) Confidence 0.34 Published 2009 Journal Scoliosis Section Abstract Doc Link PMC2781798 Disease Relevance 0.94 Pain Relevance 0

General Comments

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