INT288231

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.20
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DHFR (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 1 77.40 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mesothelioma 47 98.22 Very High Very High Very High
Cancer 6 95.04 Very High Very High Very High
Toxicity 7 86.52 High High
Leukemia 1 81.12 Quite High
Disease 20 78.96 Quite High
Immunotherapy Of Cancer 1 18.24 Low Low
Lung Cancer 1 10.60 Low Low
Mitral Valve Prolapse 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Dyspnea 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recently, the novel antifolate pralatrexate demonstrated activity in preclinical models, but not in a phase II trial in mesothelioma patients [16].The only FDA-approved agent for mesothelioma is pemetrexed, an antifolate which principally targets thymidylate synthase, as well as dihydrofolate reductase and glycinamide ribonucleotide formyltransferase.
Localization (formyltransferase) of dihydrofolate reductase associated with mesothelioma
1) Confidence 0.16 Published 2008 Journal Curr Treat Options Oncol Section Body Doc Link PMC2782121 Disease Relevance 1.20 Pain Relevance 0.04

General Comments

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