INT288233

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.17
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TYMS) mitochondrion (TYMS) small molecule metabolic process (TYMS)
aging (TYMS) cytoplasm (TYMS) cytosol (TYMS)
TYMS (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 1 78.72 Quite High
Pain 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microsatellite Instability 1 100.00 Very High Very High Very High
Colon Cancer 52 99.90 Very High Very High Very High
Mesothelioma 47 98.88 Very High Very High Very High
Cancer 57 95.04 Very High Very High Very High
Toxicity 7 87.84 High High
Leukemia 1 82.44 Quite High
Disease 28 78.96 Quite High
Breast Cancer 12 65.56 Quite High
Hyperplasia 3 61.96 Quite High
Advanced Or Metastatic Breast Cancer 1 56.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recently, the novel antifolate pralatrexate demonstrated activity in preclinical models, but not in a phase II trial in mesothelioma patients [16].The only FDA-approved agent for mesothelioma is pemetrexed, an antifolate which principally targets thymidylate synthase, as well as dihydrofolate reductase and glycinamide ribonucleotide formyltransferase.
Localization (formyltransferase) of thymidylate synthase associated with mesothelioma
1) Confidence 0.22 Published 2008 Journal Curr Treat Options Oncol Section Body Doc Link PMC2782121 Disease Relevance 1.21 Pain Relevance 0.04
The most widely studied tissue markers in CRC are thymidylate synthase, microsatellite instability, p53, K-ras and deleted in colorectal cancer (DCC), but they have not currently been recommended in routine practice for determining prognosis or predicting response to therapy [4].
Localization (deleted) of thymidylate synthase associated with colon cancer and microsatellite instability
2) Confidence 0.14 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.96 Pain Relevance 0

General Comments

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