INT288255

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.87
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CGA) small molecule metabolic process (CGA) extracellular region (CGA)
cellular nitrogen compound metabolic process (CGA) cell-cell signaling (CGA)
Anatomy Link Frequency
urine 1
CGA (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 4 95.00 High High
agonist 22 5.00 Very Low Very Low Very Low
abdominal pain 12 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ectopic Pregnancy 248 98.72 Very High Very High Very High
Reprotox - General 3 30 65.36 Quite High
Reprotox - General 2 16 52.24 Quite High
Disease 8 38.40 Quite Low
Syndrome 6 36.88 Quite Low
Reprotox - General 1 44 35.84 Quite Low
Ovarian Hyperstimulation Syndrome 22 5.00 Very Low Very Low Very Low
Polycystic Ovary Syndrome 18 5.00 Very Low Very Low Very Low
Anovulation 14 5.00 Very Low Very Low Very Low
Abdominal Pain 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lutropin alpha has a one compartment first-order process.42 Following subcutaneous administration of 150 IU lutropin alpha, a mean Cmax of 1.1 IU/L is reached after 6 hours (tmax).42 Lutropin alpha has a terminal half-life of about 18 hours and a bioavailability of 56% (following a single subcutaneous 10,000 IU dose).44

Manufacturing

Protein_catabolism (administration) of lutropin alpha associated with bioavailability
1) Confidence 0.75 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0 Pain Relevance 0.09
Lutropin alpha has a one compartment first-order process.42 Following subcutaneous administration of 150 IU lutropin alpha, a mean Cmax of 1.1 IU/L is reached after 6 hours (tmax).42 Lutropin alpha has a terminal half-life of about 18 hours and a bioavailability of 56% (following a single subcutaneous 10,000 IU dose).44

Manufacturing

Protein_catabolism (administration) of Lutropin alpha associated with bioavailability
2) Confidence 0.75 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2819896 Disease Relevance 0.05 Pain Relevance 0.09
These include degraded hCG molecules, hyper- and hypoglycosylated hCG, free subunits, large free subunits, fragments.
Protein_catabolism (degraded) of hCG
3) Confidence 0.40 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782204 Disease Relevance 0.50 Pain Relevance 0
These include degraded hCG molecules, hyper- and hypoglycosylated hCG, free subunits, large free subunits, fragments.
Protein_catabolism (degraded) of hCG
4) Confidence 0.40 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782204 Disease Relevance 0.39 Pain Relevance 0
In this study, the results indicated that the level of i-hCG was decreased and the rate of hCG isoform degradation was increased in patients with ectopic pregnancy.
Protein_catabolism (degradation) of hCG associated with ectopic pregnancy
5) Confidence 0.40 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782204 Disease Relevance 0.43 Pain Relevance 0
The ELISAs for determination of urine i-hCG levels and hCGRP/i-hCG, using monoclonal antibodies that specifically recognize the structural changes of hCG isoforms and degradation products, offer better diagnostic outcomes than hCG quantification combined with ultrasonography (80% sensitivity) which is currently known as the best diagnostic method for ectopic pregnancy (13).
Protein_catabolism (degradation) of hCG in urine associated with ectopic pregnancy
6) Confidence 0.27 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782204 Disease Relevance 0.51 Pain Relevance 0

General Comments

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