INT288317

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Context Info
Confidence 0.13
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.36
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Glyr1) nucleus (Glyr1) DNA binding (Glyr1)
cellular_component (Glyr1)
Anatomy Link Frequency
neurons 2
Glyr1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 90 100.00 Very High Very High Very High
GABA receptor 15 100.00 Very High Very High Very High
Spinal cord 167 98.04 Very High Very High Very High
Action potential 4 88.88 High High
Neurotransmitter 93 87.04 High High
Hippocampus 21 67.12 Quite High
medulla 20 66.32 Quite High
Glutamate 10 63.88 Quite High
GABAergic 51 62.36 Quite High
midbrain 25 46.64 Quite Low
Disease Link Frequency Relevance Heat
Death 3 99.92 Very High Very High Very High
Ganglion Cysts 30 90.52 High High
Generalized Anxiety Disorder 3 56.72 Quite High
Spasticity 4 44.32 Quite Low
Pain 12 5.00 Very Low Very Low Very Low
Nociception 10 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The marked differences in GlyR-mediated mIPSC amplitude in SDH and DDH neurons could be attributable to specific properties of the GlyR, such as differences in single-channel conductance, number of receptors open during quantal release (No), or channel open probability (Po).
Positive_regulation (attributable) of Gene_expression (properties) of GlyR in neurons
1) Confidence 0.13 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.09
Overexpression of GlyR subunit ?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of GlyR
2) Confidence 0.04 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.09 Pain Relevance 0.07
Since no increased cell death is observed in GlyR?
Positive_regulation (observed) of Neg (no) Gene_expression (observed) of GlyR associated with death
3) Confidence 0.03 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.21 Pain Relevance 0.03
This group reports that the observed co-IR for presynaptic glycine and GABA and postsynaptic gephyrin (as a marker for GlyR) and GABA receptors supports GABA and glycine cotransmission.
Positive_regulation (supports) of Gene_expression (presynaptic) of GlyR associated with gaba and gaba receptor
4) Confidence 0.03 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.06 Pain Relevance 0.71

General Comments

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