INT28832

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.23
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.36
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
plasma 2
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 192 100.00 Very High Very High Very High
B1 receptor 17 100.00 Very High Very High Very High
dexamethasone 23 99.98 Very High Very High Very High
agonist 28 99.96 Very High Very High Very High
b2 receptor 59 99.68 Very High Very High Very High
Inflammation 47 96.00 Very High Very High Very High
bradykinin 92 94.72 High High
cytokine 7 75.20 Quite High
Pain 8 75.00 Quite High
Analgesic 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 4 99.28 Very High Very High Very High
Pressure And Volume Under Development 11 98.64 Very High Very High Very High
INFLAMMATION 47 96.00 Very High Very High Very High
Asthma 30 87.96 High High
Pain 4 75.00 Quite High
Nicotine Addiction 24 16.28 Low Low
Pulmonary Disease 8 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This activation of plasma prekallikrein and kinin-release were inhibited in the presence of SBTI.
Negative_regulation (inhibited) of Positive_regulation (activation) of kinin-release in plasma
1) Confidence 0.23 Published 1989 Journal Agents Actions Section Abstract Doc Link 2801319 Disease Relevance 0.17 Pain Relevance 0.35
In line with this, the present data demonstrates that dexamethasone inhibited nicotine-enhanced kinin B1 and B2 receptor-mediated effects in murine airways.
Negative_regulation (inhibited) of Positive_regulation (enhanced) of kinin associated with nicotine, b2 receptor and dexamethasone
2) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.25 Pain Relevance 0.53
Our results show that SP600125 abolished the nicotine-enhanced kinin receptor-mediated contractions and the receptor mRNA expression.
Negative_regulation (abolished) of Positive_regulation (enhanced) of kinin associated with nicotine
3) Confidence 0.16 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.15 Pain Relevance 0.31
These data show that the long-term systemic treatment of mice with BCG produced dose-related potentiation of B1 receptor agonist-mediated nociception and oedema formation, without affecting similar responses caused by the B2 receptor agonist tyrosine8-bradykinin.
Negative_regulation (produced) of Positive_regulation (potentiation) of B1 receptor associated with nociception, pressure and volume under development, b1 receptor, b2 receptor, agonist and bradykinin
4) Confidence 0.09 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9844998 Disease Relevance 0.79 Pain Relevance 0.86

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox