INT288331

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Context Info
Confidence 0.09
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 6.99
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 2
spinal cord 1
brain 1
motor neurons 1
Sod1m (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 10 98.96 Very High Very High Very High
Substantia nigra 14 90.32 High High
cerebral cortex 2 89.48 High High
Hippocampus 14 88.80 High High
ischemia 2 86.40 High High
Inflammation 148 82.24 Quite High
Inflammatory mediators 42 78.96 Quite High
chemokine 16 59.72 Quite High
cytokine 72 56.60 Quite High
Inflammatory response 48 54.72 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 40 99.96 Very High Very High Very High
Stress 120 99.76 Very High Very High Very High
Disease 350 97.08 Very High Very High Very High
Disease Progression 36 95.76 Very High Very High Very High
Motor Neuron Diseases 98 94.56 High High
Death 50 94.56 High High
Nerve Degeneration 6 93.36 High High
Cv Unclassified Under Development 2 86.40 High High
Injury 26 85.28 High High
INFLAMMATION 240 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, G93A mice have a basal increase in oxidative stress due to the overexpression of its mSOD1 protein [32]–[35].
Gene_expression (overexpression) of mSOD1 associated with stress
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.31 Pain Relevance 0
Hence, when motor neurons were transfected with mSOD1, this resulted in the formation of toxic aggregates [72], [73], which were delayed by gene transfer of Hsp70 [74].
Gene_expression (transfected) of mSOD1 in motor neurons
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 1.52 Pain Relevance 0.38
For example, ablating microglial expression of mutant SOD 1 (mSOD1) or transplanting bone marrow from wild-type mice into mSOD1 transgenic mice increases the life span of mutant mice [133,134], suggesting that SOD1 mutations may indirectly contribute to neuronal death by affecting glial rather than neuronal function.
Gene_expression (expression) of mSOD1 in neuronal associated with targeted disruption and death
3) Confidence 0.05 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2784760 Disease Relevance 1.13 Pain Relevance 0.10
They injected systemic LPS, which increased TLR2 expression across the brain and spinal cord in both wild-type and mSOD1 mice, without changing mSOD expression.
Gene_expression (expression) of mSOD in spinal cord associated with spinal cord
4) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.41 Pain Relevance 0.08
For example, ablating microglial expression of mutant SOD 1 (mSOD1) or transplanting bone marrow from wild-type mice into mSOD1 transgenic mice increases the life span of mutant mice [133,134], suggesting that SOD1 mutations may indirectly contribute to neuronal death by affecting glial rather than neuronal function.
Gene_expression (expression) of mSOD1 in neuronal associated with targeted disruption and death
5) Confidence 0.03 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2784760 Disease Relevance 1.21 Pain Relevance 0.13
They injected systemic LPS, which increased TLR2 expression across the brain and spinal cord in both wild-type and mSOD1 mice, without changing mSOD expression.
Gene_expression (expression) of mSOD in brain associated with spinal cord
6) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.41 Pain Relevance 0.08

General Comments

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