INT28834

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 38
Total Number 43
Disease Relevance 30.48
Pain Relevance 26.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
plasma 2
smooth muscle 2
spinal cord 2
epithelium 2
paw 2
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 679 100.00 Very High Very High Very High
B1 receptor 299 100.00 Very High Very High Very High
Nicotine 1248 99.98 Very High Very High Very High
agonist 179 99.96 Very High Very High Very High
Inflammatory mediators 4 99.96 Very High Very High Very High
depression 193 99.84 Very High Very High Very High
Inflammation 519 99.72 Very High Very High Very High
b2 receptor 432 99.68 Very High Very High Very High
dexamethasone 144 99.60 Very High Very High Very High
Sciatic nerve 14 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 86 100.00 Very High Very High Very High
Depression 229 99.84 Very High Very High Very High
INFLAMMATION 559 99.76 Very High Very High Very High
Neuropathic Pain 48 99.76 Very High Very High Very High
Injury 59 99.56 Very High Very High Very High
Nicotine Addiction 156 99.44 Very High Very High Very High
Targeted Disruption 92 99.44 Very High Very High Very High
Disease 71 99.40 Very High Very High Very High
Nociception 64 99.28 Very High Very High Very High
Hyperalgesia 36 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Partial sciatic nerve ligation induced an upregulation in B1 receptor mRNA in ipsilateral paw, sciatic nerve, and spinal cord of wild-type mice.
Positive_regulation (upregulation) of B1 receptor mRNA in sciatic nerve associated with b1 receptor, sciatic nerve and spinal cord
1) Confidence 0.69 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15745967 Disease Relevance 1.02 Pain Relevance 1.31
Moreover, it has been demonstrated that B1R activation can enhance the release of prostaglandins [16], mast cell mediators [15], cytokines, mainly IL-1?
Positive_regulation (activation) of B1R in mast cell associated with cytokine
2) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.64 Pain Relevance 0.75
Moreover, PMA treatment did not alter B1 receptor mRNA levels, but greatly increased B1 receptor protein levels in the mouse paw.
Neg (not) Positive_regulation (increased) of B1 receptor in paw associated with b1 receptor
3) Confidence 0.59 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18164734 Disease Relevance 0.87 Pain Relevance 0.79
The results of these studies revealed the presence of B1R mRNA throughout the rostral-caudal extent of the brain and spinal cord.
Positive_regulation (presence) of B1R mRNA in spinal cord associated with spinal cord
4) Confidence 0.50 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12966562 Disease Relevance 0.37 Pain Relevance 0.60
Most studies performed to investigate the role of the inducible bradykinin B(1) receptor in the pathology and complications of type 1 diabetes have been carried out using the model of streptozotocin (STZ)-induced diabetes.
Spec (investigate) Positive_regulation (inducible) of bradykinin B associated with diabetes mellitus and bradykinin
5) Confidence 0.50 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15878325 Disease Relevance 1.35 Pain Relevance 0.32
Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors.
Positive_regulation (relevance) of kinin B1 in brachial plexus associated with neuropathic pain
6) Confidence 0.48 Published 2008 Journal J. Neurosci. Section Title Doc Link 18337416 Disease Relevance 0.19 Pain Relevance 0.68
We also evaluated the implication of the bradykinin B(1) receptor, a receptor up-regulated during the inflammatory progress of diabetes, in the development of diabetic hyperalgesia in NOD mice.
Positive_regulation (up-regulated) of bradykinin B associated with hyperalgesia, inflammation, diabetes mellitus and bradykinin
7) Confidence 0.46 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15878325 Disease Relevance 2.35 Pain Relevance 0.71
Together, kinin B1 receptor activation seems to be essential to neuropathic pain development, suggesting that an oral-selective B1 receptor antagonist might have therapeutic potential in the management of chronic pain.
Positive_regulation (activation) of B1 receptor associated with lasting pain, antagonist, b1 receptor and neuropathic pain
8) Confidence 0.43 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15745967 Disease Relevance 0.98 Pain Relevance 1.28
Since the PKC pathway is downstream of several pro-inflammatory mediators, B1 receptor stimulation appears to contribute to the acute inflammatory pain process.
Positive_regulation (stimulation) of B1 receptor associated with inflammatory mediators, kinase c, ipn and b1 receptor
9) Confidence 0.42 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18164734 Disease Relevance 0.79 Pain Relevance 0.79
Mechanisms of nociception were studied using the combination of knockout mice, selective drugs, and measurement of B1 receptor mRNA and protein levels.
Positive_regulation (measurement) of B1 receptor mRNA associated with targeted disruption, nociception and b1 receptor
10) Confidence 0.42 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18164734 Disease Relevance 0.77 Pain Relevance 0.68
B2R are constitutively expressed, while B1R are inducible.
Positive_regulation (inducible) of B1R
11) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 0.93 Pain Relevance 0.38
Other studies have associated B1R activation with enhanced inflammation [29], [36], [37].
Positive_regulation (activation) of B1R associated with inflammation
12) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.34 Pain Relevance 0.35
The bradykinin B(1) receptor was recently found to be upregulated during the development of the diabetes and to be involved in its complications.
Positive_regulation (upregulated) of bradykinin B associated with diabetes mellitus and bradykinin
13) Confidence 0.40 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12464357 Disease Relevance 1.45 Pain Relevance 0.58
By use of selective agonists and antagonists, we revealed that BK nociception in sham-operated mice was mediated through B2 receptor, whereas that in injured mice was mediated through B1 receptor.
Positive_regulation (mediated) of B1 receptor associated with nociception, b1 receptor, antagonist, b2 receptor, agonist and bradykinin
14) Confidence 0.38 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14634040 Disease Relevance 0.90 Pain Relevance 1.04
Experimental evidence has shown that the bradykinin B1 receptor (BKB1-R) is involved in the development of type 1 diabetes and found to be upregulated alongside the disease.
Positive_regulation (upregulated) of bradykinin B1 receptor associated with diabetes mellitus, b1 receptor and disease
15) Confidence 0.34 Published 2010 Journal Neuropeptides Section Abstract Doc Link 20092893 Disease Relevance 1.65 Pain Relevance 0.43
and B1 receptor upregulation [10,14], we further investigated the role played by TNF?
Spec (investigated) Positive_regulation (upregulation) of B1 receptor associated with b1 receptor
16) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3022820 Disease Relevance 0.30 Pain Relevance 0.23
Stimulation of kinin B1 and B2 receptors on the airway smooth muscle directly activates the inositol 1,4,5-trisphosphate (IP3) pathway increasing intracellular Ca2+ levels which subsequently activates the cellular contractile machinery [18].
Positive_regulation (Stimulation) of kinin in smooth muscle
17) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.38 Pain Relevance 0.49
This activation of plasma prekallikrein and kinin-release were inhibited in the presence of SBTI.
Positive_regulation (activation) of kinin-release in plasma
18) Confidence 0.25 Published 1989 Journal Agents Actions Section Abstract Doc Link 2801319 Disease Relevance 0.17 Pain Relevance 0.35
Partial sciatic nerve ligation induced an upregulation in B1 receptor mRNA in ipsilateral paw, sciatic nerve, and spinal cord of wild-type mice.
Positive_regulation (upregulation) of B1 receptor mRNA in paw associated with b1 receptor, sciatic nerve and spinal cord
19) Confidence 0.23 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15745967 Disease Relevance 1.02 Pain Relevance 1.31
Partial sciatic nerve ligation induced an upregulation in B1 receptor mRNA in ipsilateral paw, sciatic nerve, and spinal cord of wild-type mice.
Positive_regulation (upregulation) of B1 receptor mRNA in spinal cord associated with b1 receptor, sciatic nerve and spinal cord
20) Confidence 0.23 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15745967 Disease Relevance 1.02 Pain Relevance 1.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox