INT288356

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Context Info
Confidence 0.45
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Mgrn1) plasma membrane (Mgrn1) nucleus (Mgrn1)
ligase activity (Mgrn1) cytoplasm (Mgrn1)
Anatomy Link Frequency
melanocytes 1
Mgrn1 (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 58 94.56 High High
Kinase C 2 69.92 Quite High
agonist 8 44.40 Quite Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 4 71.76 Quite High
Sprains And Strains 10 40.84 Quite Low
Vibrio Infection 6 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Microphthalmia 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Agouti signaling protein (ASIP)’s morphological effects were very deficient in MGRN1-null melanocytes, consistent with the requirement of MGRN1 for ASIP action in mice.
Positive_regulation (requirement) of MGRN1 in melanocytes
1) Confidence 0.45 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.07 Pain Relevance 0.29
Interestingly, both 100 nM ASIP and 100 nM ASIP-YY completely inhibited the MSH-induced cAMP rise in both genotypes, implying that this inhibition requires neither ATRN nor MGRN1.


Neg (neither) Positive_regulation (requires) of MGRN1
2) Confidence 0.36 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0

General Comments

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