INT288357

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Context Info
Confidence 0.17
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Dct) isomerase activity (Dct) cytosol (Dct)
oxidoreductase activity (Dct) cytoplasm (Dct)
Dct (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 29 80.60 Quite High
agonist 4 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 2 43.84 Quite Low
Vibrio Infection 3 19.92 Low Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Microphthalmia 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melan-a cells treated with ASIP lose expression of TYRP1, DCT, and SILV/PMEL, all needed to generate normal eumelanosomes but not pheomelanosomes, while retaining low tyrosinase expression (Sakai et al., 1997) which would favor pheomelanogenesis (Ito, 2003).
Negative_regulation (lose) of Gene_expression (expression) of DCT
1) Confidence 0.17 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.08

General Comments

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