INT288383

Context Info Confidence 0.18 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.99 Pain Relevance 0

extracellular space (CHIT1) extracellular region (CHIT1) carbohydrate metabolic process (CHIT1) lysosome (CHIT1)

CHIT1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory response 4 9.84 Inflammation 22 5.00 cytokine 20 5.00 Inflammatory stimuli 8 5.00 tolerance 6 5.00 fibrosis 2 5.00 Pain 2 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Infection 42 99.06 Lymphatic Filariasis 50 93.68 Disease 12 92.92 Lymphedema 98 87.36 Filariasis 12 87.08 Hydrocele 56 73.76 Helminth Infection 50 16.00 INFLAMMATION 36 9.48 Death 12 5.00 Fever 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Choi et al. have shown in a study in South India that patients are more susceptible to W. bancrofti infection if they are homozygous for the allele that is responsible for lower levels of chitotriosidase (CHIT1), a protein found in phagocytic cells (73).

Regulation (responsible) of Gene_expression (levels) of chitotriosidase associated with infection

1) Confidence 0.18 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2784903 Disease Relevance 1.50 Pain Relevance 0

Choi et al. have shown in a study in South India that patients are more susceptible to W. bancrofti infection if they are homozygous for the allele that is responsible for lower levels of chitotriosidase (CHIT1), a protein found in phagocytic cells (73).

Regulation (responsible) of Gene_expression (levels) of CHIT1 associated with infection

2) Confidence 0.14 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2784903 Disease Relevance 1.50 Pain Relevance 0

General Comments

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