INT28843

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 31
Total Number 34
Disease Relevance 5.35
Pain Relevance 10.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn2a1)
Anatomy Link Frequency
SCN 7
neurons 6
brain 2
neuronal 2
ScN 2
Scn2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe 189 100.00 Very High Very High Very High
Sciatic nerve 12 100.00 Very High Very High Very High
Glutamate receptor 50 99.98 Very High Very High Very High
gABA 286 99.84 Very High Very High Very High
opioid receptor 43 99.80 Very High Very High Very High
GABAergic 29 99.68 Very High Very High Very High
Glutamate 293 99.56 Very High Very High Very High
Action potential 74 99.54 Very High Very High Very High
c fibre 4 99.52 Very High Very High Very High
Neurotransmitter 869 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 100.00 Very High Very High Very High
Aids-related Complex 10 99.96 Very High Very High Very High
Bradycardia 28 99.48 Very High Very High Very High
Graves' Ophthalmopathy 9 97.80 Very High Very High Very High
Shock 6 94.88 High High
Targeted Disruption 60 94.44 High High
Neuroleptic Malignant Syndrome 45 92.76 High High
Anxiety Disorder 15 91.64 High High
Ganglion Cysts 54 84.76 Quite High
Sleep Disorders 306 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BVB was largely inhibited by activation of A delta-fibers of the ScN or SU, but C-fiber contribution to BVB inhibition was also ascertained by means of selective C-fiber activation.
Positive_regulation (activation) of ScN in ScN associated with c fibre, sciatic nerve and bradycardia
1) Confidence 0.68 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2802001 Disease Relevance 1.21 Pain Relevance 0.61
These genes are rapidly induced in the SCN by light stimulation at those time points at which light phase shifts the clock.
Positive_regulation (induced) of SCN
2) Confidence 0.43 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.12 Pain Relevance 0.24
On the other hand, GluR antagonists block light-induced phase shifts and Fos-induction in the SCN in vivo [56,57].
Positive_regulation (induction) of SCN associated with antagonist and glutamate receptor
3) Confidence 0.43 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.08 Pain Relevance 0.62
Postsynaptic currents in SCN neurons were also evoked by the selective stimulation of other SCN neurons with glutamate, which avoids direct activation of axons that might originate outside the SCN.
Positive_regulation (stimulation) of SCN in SCN associated with glutamate
4) Confidence 0.41 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9325388 Disease Relevance 0 Pain Relevance 0.40
Stimulation of the optic nerve released 3H-Glu, 3H-Asp but not 3H-GABA, while stimulation of the SCN released all three.
Positive_regulation (stimulation) of SCN in SCN associated with gaba
5) Confidence 0.40 Published 1986 Journal Brain Res. Bull. Section Abstract Doc Link 2872946 Disease Relevance 0 Pain Relevance 0.34
Regardless of whether the spinal cord was hemisectioned on any side with respect to the target reflex arc, stimulation of the ScN of either side still inhibited BVB, unless the lateral funiculus of nonsectioned side was extensively lesioned.
Positive_regulation (stimulation) of ScN in ScN associated with aids-related complex, sciatic nerve, bradycardia and spinal cord
6) Confidence 0.40 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2802001 Disease Relevance 1.12 Pain Relevance 0.57
Heat pulses were administered at various circadian times (CTs) by increasing SCN temperature from 34 to 37 degrees C for 2 hr.
Positive_regulation (increasing) of SCN in SCN
7) Confidence 0.32 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10493763 Disease Relevance 0 Pain Relevance 0.09
Possible targets for some of the neurotransmitters are the clock genes per1 and per2, which are induced in the SCN by light or by neurotransmitters, at night.
Positive_regulation (induced) of SCN associated with neurotransmitter
8) Confidence 0.31 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.73
Intensive interconnection and interaction among the heterogeneous neuronal elements is responsible for the functional output of the SCN.
Positive_regulation (responsible) of SCN in neuronal
9) Confidence 0.31 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.71
Possible genes for glutamate and PACAP thus appear to be the clock genes per1 and per2, which are induced in the SCN by light, glutamate and PACAP at night.
Positive_regulation (induced) of SCN associated with glutamate
10) Confidence 0.31 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.39 Pain Relevance 0.27
This is interesting since there are studies showing that NPY immunoreactive terminals overlap with NT-binding sites in the ventral part of the SCN.
Positive_regulation (part) of SCN in ventral
11) Confidence 0.31 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.13 Pain Relevance 0.39
We find that vasoactive intestinal peptide (VIP) and a VPAC2 (VIP receptor subtype 2) receptor-specific agonist, Ro-25-1553, are the most effective ligands tested in evoking a cAMP-mitogen-activated protein kinase signal transduction cascade leading to an increase in VP gene transcription in the SCN.
Positive_regulation (increase) of SCN in SCN associated with agonist
12) Confidence 0.30 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17202481 Disease Relevance 0 Pain Relevance 0.53
Light also induces clock gene expression in the SCN but only during the night [8,249].
Positive_regulation (induces) of SCN
13) Confidence 0.29 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.06
It may act to modulate the photic information reaching the SCN.


Positive_regulation (reaching) of SCN
14) Confidence 0.29 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.31
Intracerebroventricular administration of neuromedin S in rats activates SCN neurons and has the capability to induce non-photic type of phase shifts in the circadian rhythm of locomotor activity.
Positive_regulation (activates) of SCN in neurons associated with eae and intracerebroventricular
15) Confidence 0.29 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.41 Pain Relevance 0.27
In addition, a subset of SPZ neurons showed an increase in the amplitude of SCN-evoked GABAergic inhibitory postsynaptic currents (IPSCs) and a decrease in their paired-pulse ratios.
Positive_regulation (increase) of SCN in SCN associated with gabaergic
16) Confidence 0.29 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19571188 Disease Relevance 0 Pain Relevance 0.31
Our experimental studies demonstrated that Ca2+ spikes, having a typical bandwidth of tens of seconds, could be induced in SCN neurons by the Ca2+ chelating effect of BAPTA-based dyes.
Positive_regulation (induced) of SCN in neurons
17) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0
On the other hand, Aguilar-Roblero et al. [28] have demonstrated that AP firing frequencies in SCN neurons can be increased by ryanodine receptor activators (e.g., caffeine) and decreased by ryanodine receptor blockers (e.g., dantrolene): in other words, the mobilization of Ca2+ store by ryanodine-sensitive intracellular Ca2+ channels can modulate AP firing rate.
Positive_regulation (increased) of SCN in neurons associated with action potential
18) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.51
The increase in 5-HT synthesis observed in the MPO, SCN, AN, and ST 1 hour following morphine involved the activation of opiate receptors as administration of an opiate receptor antagonist, naloxone, blocked this effect.
Positive_regulation (increase) of SCN associated with antagonist, narcan, urological neuroanatomy, opiate and morphine
19) Confidence 0.28 Published 1983 Journal J. Neural Transm. Section Abstract Doc Link 6619831 Disease Relevance 0.28 Pain Relevance 1.05
Because little SAAS is released from the horizontal SCN brain slice when the attached optic nerves innervating the SCN are stimulated, little SAAS could be a neurochemical messenger of retinohypothalamic tract (RHT) signaling from the eye.
Positive_regulation (stimulated) of SCN in brain
20) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0.13 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox