INT288483

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Context Info
Confidence 0.72
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.51
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tlr3) cytoplasm (Tlr3)
Anatomy Link Frequency
whiskers 3
proximal 1
motor neurons 1
Tlr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 6 91.44 High High
spastic colon 127 90.68 High High
Inflammatory mediators 6 81.52 Quite High
Inflammation 112 81.24 Quite High
Crohn's disease 1 76.52 Quite High
cytokine 69 56.60 Quite High
nud 9 43.36 Quite Low
fifth nerve 18 5.00 Very Low Very Low Very Low
isoflurane 13 5.00 Very Low Very Low Very Low
trigeminal ganglion 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Viral Meningitis 192 99.62 Very High Very High Very High
Stress 60 98.72 Very High Very High Very High
Sprains And Strains 294 98.52 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

126 90.68 High High
Cold Sores 366 86.00 High High
Infection 186 82.20 Quite High
INFLAMMATION 131 81.60 Quite High
Disease 25 76.52 Quite High
Inflammatory Bowel Disease 9 75.76 Quite High
Viral Infection 6 68.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In peripheral nerves Schwann cells express high levels of TLRs, with TLR3 and -4 being the most prominent, whereas in sensory and motor neurons the levels are minimal [10].
Gene_expression (express) of TLR3 in motor neurons
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.56 Pain Relevance 0.15
Baseline expression of Tlr3 in naïve animals was higher in DA, than in PVG rats.
Gene_expression (expression) of Tlr3
2) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.27 Pain Relevance 0.04
Tlr3 expressed in cell endosomes recognizes double-stranded RNA.
Gene_expression (expressed) of Tlr3
3) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.33 Pain Relevance 0.04
However, in our HSE model an elevated expression of Tlr3 in the whiskers area was seen in the susceptible rat and we hypothesized that the susceptibility was not caused by low expression of Tlr3.
Gene_expression (expression) of Tlr3 in whiskers associated with viral meningitis
4) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.79 Pain Relevance 0.04
The levels of Tlr3 were increased at 12 hpi and 1 dpi in the whiskers area of the DA rats, while differences were significant also at later time points in PVG rats.
Gene_expression (levels) of Tlr3 in whiskers
5) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.33 Pain Relevance 0.04
However, in our HSE model an elevated expression of Tlr3 in the whiskers area was seen in the susceptible rat and we hypothesized that the susceptibility was not caused by low expression of Tlr3.
Gene_expression (expression) of Tlr3 in whiskers associated with viral meningitis
6) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.81 Pain Relevance 0.04
Comparing mRNA levels, we see a significant difference in the levels of TLR3, the receptor for dsRNA [40], in the proximal (p?
Gene_expression (levels) of TLR3 in proximal
7) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.31 Pain Relevance 0
The authors used 2 different models (maternal separation and stress susceptible Wistar-Kyoto rats), showing a significantly higher expression of the TLR3, 4 and 5 on both, while the Wistar-Kyoto which are genetically susceptible to stress, also had a significant over expression in the TLRs 7, 8 and 9 compared to the Sprague-Dawley which are not genetically susceptible to stress.
Gene_expression (expression) of TLR3 associated with stress
8) Confidence 0.37 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.57 Pain Relevance 0.62

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