INT288483
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In peripheral nerves Schwann cells express high levels of TLRs, with TLR3 and -4 being the most prominent, whereas in sensory and motor neurons the levels are minimal [10]. | |||||||||||||||
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Baseline expression of Tlr3 in naïve animals was higher in DA, than in PVG rats. | |||||||||||||||
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Tlr3 expressed in cell endosomes recognizes double-stranded RNA. | |||||||||||||||
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However, in our HSE model an elevated expression of Tlr3 in the whiskers area was seen in the susceptible rat and we hypothesized that the susceptibility was not caused by low expression of Tlr3. | |||||||||||||||
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The levels of Tlr3 were increased at 12 hpi and 1 dpi in the whiskers area of the DA rats, while differences were significant also at later time points in PVG rats. | |||||||||||||||
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However, in our HSE model an elevated expression of Tlr3 in the whiskers area was seen in the susceptible rat and we hypothesized that the susceptibility was not caused by low expression of Tlr3. | |||||||||||||||
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Comparing mRNA levels, we see a significant difference in the levels of TLR3, the receptor for dsRNA [40], in the proximal (p? | |||||||||||||||
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The authors used 2 different models (maternal separation and stress susceptible Wistar-Kyoto rats), showing a significantly higher expression of the TLR3, 4 and 5 on both, while the Wistar-Kyoto which are genetically susceptible to stress, also had a significant over expression in the TLRs 7, 8 and 9 compared to the Sprague-Dawley which are not genetically susceptible to stress. | |||||||||||||||
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