INT288484

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.19
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
proximal 2
lymphocyte 1
colon 1
Tlr8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 195 98.86 Very High Very High Very High
Crohn's disease 1 90.44 High High
Inflammation 83 88.20 High High
nud 21 79.72 Quite High
cytokine 64 50.00 Quite Low
abdominal pain 8 17.84 Low Low
Catecholamine 7 5.00 Very Low Very Low Very Low
noradrenaline 6 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

194 98.86 Very High Very High Very High
Agammaglobulinemia 1 97.36 Very High Very High Very High
Obesity 229 94.76 High High
Disease 6 90.44 High High
Inflammatory Bowel Disease 9 89.68 High High
INFLAMMATION 86 88.20 High High
Sprains And Strains 36 83.20 Quite High
Genetic Predisposition To Disease 50 83.16 Quite High
Stress 160 79.92 Quite High
Dyspepsia 21 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
0.0203) (Figure 4a & 4b), TLR8 in the proximal (p<0.0001) and the distal colonic mucosa (p<0.0001) (Figure 4c & 4d), TLR9 in the proximal (p?
Gene_expression (proximal) of TLR8 in proximal
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.70 Pain Relevance 0.04
0.0203) (Figure 4a & 4b), TLR8 in the proximal (p<0.0001) and the distal colonic mucosa (p<0.0001) (Figure 4c & 4d), TLR9 in the proximal (p?
Gene_expression (0.0203) of TLR8 in proximal
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.69 Pain Relevance 0.04
Recently, Brint et al,81 reported a 5-fold up-regulation of TLR4 in women with IBS compared to healthy controls, while reporting a reduced expression of TLR7 and TLR8 in the same patients.
Gene_expression (expression) of TLR8 associated with spastic colon
3) Confidence 0.41 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.54 Pain Relevance 0.72
While TLR8 was significantly increased in the proximal but not the distal colon (p?
Neg (not) Gene_expression (was) of TLR8 in colon
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.59 Pain Relevance 0.04
Genes that belong to this pathway are Toll-like receptor 5, 7, and 8 (TLR5, TLR7, TLR8), CD14 molecule (CD14), lymphocyte antigen 96 (LY96; also known as MD-2), Bruton agammaglobulinemia tyrosine kinase (BTK) [29], and myeloid differentiation primary response gene (88) (Myd88).
Gene_expression (molecule) of TLR8 in lymphocyte associated with agammaglobulinemia
5) Confidence 0.18 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2925326 Disease Relevance 1.04 Pain Relevance 0

General Comments

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