INT288486

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.76
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
colon 2
Tlr8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 127 99.02 Very High Very High Very High
Crohn's disease 1 90.76 High High
Inflammation 46 88.52 High High
nud 9 74.00 Quite High
cytokine 33 50.00 Quite Low
chemokine 6 5.00 Very Low Very Low Very Low
abdominal pain 4 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Visceral pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

126 99.02 Very High Very High Very High
Disease 1 90.76 High High
Inflammatory Bowel Disease 9 90.00 High High
INFLAMMATION 47 88.52 High High
Sprains And Strains 12 83.20 Quite High
Stress 60 79.92 Quite High
Genetic Predisposition To Disease 18 79.84 Quite High
Dyspepsia 9 74.00 Quite High
Congenital Anomalies 8 66.24 Quite High
Gastroenteritis 4 19.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, Brint et al,81 reported a 5-fold up-regulation of TLR4 in women with IBS compared to healthy controls, while reporting a reduced expression of TLR7 and TLR8 in the same patients.
Negative_regulation (reduced) of Gene_expression (expression) of TLR8 associated with spastic colon
1) Confidence 0.29 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.54 Pain Relevance 0.72
While TLR8 was significantly increased in the proximal but not the distal colon (p?
Negative_regulation (While) of Neg (not) Gene_expression (was) of TLR8 in colon
2) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.59 Pain Relevance 0.04

General Comments

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