INT288489

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Context Info
Confidence 0.51
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 3.85
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tlr3) cytoplasm (Tlr3)
Anatomy Link Frequency
proximal 3
Tlr3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nud 24 95.40 Very High Very High Very High
Inflammation 64 90.20 High High
cytokine 60 83.84 Quite High
spastic colon 136 82.24 Quite High
abdominal pain 8 10.52 Low Low
Catecholamine 8 5.00 Very Low Very Low Very Low
noradrenaline 8 5.00 Very Low Very Low Very Low
Neuropathic pain 4 5.00 Very Low Very Low Very Low
glial activation 4 5.00 Very Low Very Low Very Low
allodynia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genetic Predisposition To Disease 64 99.42 Very High Very High Very High
Sprains And Strains 48 99.38 Very High Very High Very High
Dyspepsia 24 95.40 Very High Very High Very High
Stress 196 93.48 High High
INFLAMMATION 64 90.20 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

136 82.24 Quite High
Functional Bowel Disorder 16 54.56 Quite High
Anxiety Disorder 4 22.36 Low Low
Syndrome 4 19.32 Low Low
Abdominal Pain 8 10.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WKY animals have increased mRNA expression of TLR3 in the proximal (p?
Transcription (expression) of TLR3 in proximal associated with genetic predisposition to disease
1) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.58 Pain Relevance 0.05
Significant increases are seen in the mRNA levels of TLR3, 4 & 5 in both the distal and proximal colonic mucosa of MS rats compared with controls.
Transcription (levels) of TLR3 in proximal
2) Confidence 0.46 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2785428 Disease Relevance 1.08 Pain Relevance 0.27
The WKY strain have increased levels of mRNA expression of TLR3, 4, 5, 7, 8, 9 & 10 in both the distal and proximal colonic mucosa compared to the control Sprague-Dawley strain.
Transcription (expression) of TLR3 in proximal associated with sprains and strains
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2785428 Disease Relevance 1.14 Pain Relevance 0.14
In particular we demonstrate that both models display changes in the mRNA expression of TLR3, 4 and 5.
Transcription (expression) of TLR3
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.52 Pain Relevance 0.60

General Comments

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