INT288493

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Context Info
Confidence 0.66
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.38
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tlr2) cytoplasm (Tlr2)
Anatomy Link Frequency
dendritic cells 3
whiskers 2
brain stem 2
epithelial cells 2
monocytes 1
Tlr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 81 97.76 Very High Very High Very High
cytokine 63 97.24 Very High Very High Very High
Inflammatory mediators 3 93.36 High High
Catecholamine 6 83.16 Quite High
noradrenaline 6 78.00 Quite High
Inflammatory marker 3 62.08 Quite High
nud 18 60.32 Quite High
spastic colon 102 43.76 Quite Low
Opioid 3 31.92 Quite Low
depression 3 9.20 Low Low
Disease Link Frequency Relevance Heat
Stress 147 99.62 Very High Very High Very High
INFLAMMATION 90 97.76 Very High Very High Very High
Sprains And Strains 177 97.24 Very High Very High Very High
Cold Sores 183 95.08 Very High Very High Very High
Genetic Predisposition To Disease 48 91.56 High High
Viral Infection 3 80.04 Quite High
Infection 108 76.40 Quite High
Viral Meningitis 96 69.76 Quite High
Dehydration 3 65.28 Quite High
Dyspepsia 18 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In DA rats increased expression of Tlr2 was observed in the trigeminal ganglia at 2 dpi and in the brain stem at 4 dpi, while the expression in PVG rats was unchanged.
Positive_regulation (increased) of Gene_expression (expression) of Tlr2 in brain stem
1) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.35 Pain Relevance 0.04
In the whiskers area of DA rats the increase of cell surface Tlr2 expression was delayed starting from 2 dpi, while in PVG rats an increase was evident from 1 dpi.
Positive_regulation (increase) of Gene_expression (expression) of Tlr2 in whiskers
2) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.32 Pain Relevance 0.05
Notably, the levels of Tlr2 and -9 were higher in the resistant PVG rats (Figure 5A and 5D).
Positive_regulation (higher) of Gene_expression (levels) of Tlr2
3) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.60 Pain Relevance 0.09
Few studies have investigated the impact of chronic stress on TLR expression and function, however of those that have done so, repeated social defeat stress has been shown to increase the expression of TLR2 and TLR4 [19] and increase TLR-mediated release of pro-inflammatory cytokines from splenic monocytes and dendritic cells [20].
Positive_regulation (increase) of Gene_expression (expression) of TLR2 in dendritic cells associated with stress, inflammation and cytokine
4) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.98 Pain Relevance 0.31
[56] or H. influenzae [57] to enhance the expression of TLR2 in human colonic or alveolar epithelial cells.
Positive_regulation (enhance) of Gene_expression (expression) of TLR2 in epithelial cells
5) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 1.16 Pain Relevance 0.15
Few studies have investigated the impact of chronic stress on TLR expression and function, however of those that have done so, repeated social defeat stress has been shown to increase the expression of TLR2 and TLR4 [19] and increase TLR-mediated release of pro-inflammatory cytokines from splenic monocytes and dendritic cells [20].
Positive_regulation (increase) of in monocytes Gene_expression (expression) of TLR2 in dendritic cells associated with stress, inflammation and cytokine
6) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.98 Pain Relevance 0.31

General Comments

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