INT288495

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.83
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr7) signal transduction (Tlr7) endoplasmic reticulum (Tlr7)
plasma membrane (Tlr7) intracellular (Tlr7) lysosome (Tlr7)
Anatomy Link Frequency
lymphocyte 1
proximal 1
Tlr7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 127 98.86 Very High Very High Very High
Crohn's disease 1 90.44 High High
Inflammation 51 88.20 High High
nud 9 83.04 Quite High
cytokine 34 50.00 Quite Low
abdominal pain 4 8.96 Low Low
chemokine 6 5.00 Very Low Very Low Very Low
Catecholamine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Visceral pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

126 98.86 Very High Very High Very High
Agammaglobulinemia 1 97.36 Very High Very High Very High
Obesity 229 95.00 High High
Disease 6 90.44 High High
Inflammatory Bowel Disease 9 89.68 High High
INFLAMMATION 54 88.20 High High
Genetic Predisposition To Disease 18 86.48 High High
Dyspepsia 9 83.04 Quite High
Stress 62 79.20 Quite High
Sarcoma 1 79.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover the expression of TLR7 in the proximal (p?
Gene_expression (expression) of TLR7 in proximal
1) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2785428 Disease Relevance 0.63 Pain Relevance 0.04
Recently, Brint et al,81 reported a 5-fold up-regulation of TLR4 in women with IBS compared to healthy controls, while reporting a reduced expression of TLR7 and TLR8 in the same patients.
Gene_expression (expression) of TLR7 associated with spastic colon
2) Confidence 0.42 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.53 Pain Relevance 0.72
Genes that belong to this pathway are Toll-like receptor 5, 7, and 8 (TLR5, TLR7, TLR8), CD14 molecule (CD14), lymphocyte antigen 96 (LY96; also known as MD-2), Bruton agammaglobulinemia tyrosine kinase (BTK) [29], and myeloid differentiation primary response gene (88) (Myd88).
Gene_expression (molecule) of TLR7 in lymphocyte associated with agammaglobulinemia
3) Confidence 0.22 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2925326 Disease Relevance 1.04 Pain Relevance 0

General Comments

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