INT288508

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.62
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
neuronal 2
neurons 2
Nefh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 116 100.00 Very High Very High Very High
Hyperalgesia 2 27.20 Quite Low
allodynia 2 26.52 Quite Low
hyperexcitability 2 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 116 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 48 97.92 Very High Very High Very High
Frailty 8 96.48 Very High Very High Very High
Neurodegenerative Disease 2 95.72 Very High Very High Very High
Toxicity 4 86.80 High High
Hyperalgesia 2 27.20 Quite Low
Neuropathic Pain 4 26.52 Quite Low
Syndrome 2 16.28 Low Low
Ataxia 2 11.40 Low Low
Peripheral Neuropathy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the loss of neuronal pNF-H expression demonstrated in the current study may be causally linked to the decreased size profiles of DRG neurons and reduced sensory nerve conduction velocity, which are induced by chronic oxaliplatin treatment in rodent models [8,9,12].
Negative_regulation (loss) of Gene_expression (expression) of pNF-H in neurons associated with dorsal root ganglion
1) Confidence 0.49 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 0.59 Pain Relevance 0.13
In this paper, we report that neuronal pNF-H expression, as determined by RT97 immunohistochemistry of rat DRG tissue, was significantly reduced after oxaliplatin treatment.
Negative_regulation (reduced) of Gene_expression (expression) of pNF-H in neuronal associated with dorsal root ganglion
2) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785764 Disease Relevance 1.03 Pain Relevance 0.30

General Comments

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