INT28851

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 1.21
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTRC)
Anatomy Link Frequency
spinal cord 1
brain 1
bile 1
mononuclear cells 1
CTRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 1 99.80 Very High Very High Very High
Spinal cord 4 98.64 Very High Very High Very High
narcan 4 96.40 Very High Very High Very High
Central nervous system 8 90.84 High High
Opioid 2 66.56 Quite High
anesthesia 2 53.60 Quite High
peripheral neuropathy 13 5.00 Very Low Very Low Very Low
dexamethasone 10 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 8 97.52 Very High Very High Very High
Plasmacytoma 1 87.24 High High
Apoptosis 11 82.04 Quite High
Multiple Myeloma 9 81.76 Quite High
Cancer 12 80.40 Quite High
Hematologic Neoplasms 1 76.56 Quite High
Appetite Loss 1 51.84 Quite High
Frailty 1 51.48 Quite High
Disorder Of Lipid Metabolism 4 46.04 Quite Low
Adhesions 2 9.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Solution B and C caused similar decreases in lipase, chymotrypsin and bile salt outputs.
Negative_regulation (decreases) of chymotrypsin in bile associated with bile
1) Confidence 0.27 Published 1993 Journal Clin Nutr Section Abstract Doc Link 16843272 Disease Relevance 0 Pain Relevance 0.29
[The inhibitory effect of elastase on calcium increase in brain and spinal cord of rabbits with atherosclerosis induced by cholesterol-rich diet].
Negative_regulation (effect) of elastase in brain associated with increased venous pressure under development and spinal cord
2) Confidence 0.01 Published 1989 Journal No To Shinkei Section Title Doc Link 2803833 Disease Relevance 0.25 Pain Relevance 0.22
Relative to controls, bortezomib treatment resulted in improved overall survival.7 A fluorogenic pharamacodynamic assay was developed to measure the relative chymotryptic and tryptic activities of the proteasome in peripheral blood mononuclear cells.8 This assay showed that bortezomib-mediated inhibition of the chymotrypsin-like activity of the 26S mammalian proteasome (Figure 1B) was dose-dependent and reversible,7 thus helping guide dosing and optimize dose escalation in phase I studies.


Negative_regulation (inhibition) of chymotrypsin in mononuclear cells
3) Confidence 0.01 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.71 Pain Relevance 0
[The inhibitory effect of elastase on calcium increase in brain and spinal cord of rabbits with atherosclerosis induced by cholesterol-rich diet].
Negative_regulation (effect) of elastase in spinal cord associated with increased venous pressure under development and spinal cord
4) Confidence 0.00 Published 1989 Journal No To Shinkei Section Title Doc Link 2803833 Disease Relevance 0.25 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox