INT288514

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 1.91
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gch1) nucleolus (Gch1) nucleus (Gch1)
protein complex assembly (Gch1) protein complex (Gch1) cytoplasm (Gch1)
Anatomy Link Frequency
DRG 3
Gch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GCH1 224 100.00 Very High Very High Very High
dorsal root ganglion 64 99.76 Very High Very High Very High
Pain 184 99.48 Very High Very High Very High
Sciatic nerve 60 95.12 Very High Very High Very High
Neuropathic pain 56 91.04 High High
Tetrahydrobiopterin 16 79.12 Quite High
tolerance 4 62.80 Quite High
algogenic 4 57.76 Quite High
Opioid 4 53.12 Quite High
cINOD 4 52.60 Quite High
Disease Link Frequency Relevance Heat
Pain 208 99.48 Very High Very High Very High
Ganglion Cysts 64 99.28 Very High Very High Very High
Neuropathic Pain 68 91.04 High High
Nervous System Injury 52 85.40 High High
Cytomegalovirus Infection 8 79.60 Quite High
Neurodegenerative Disease 8 51.28 Quite High
Hyperalgesia 4 47.32 Quite Low
INFLAMMATION 40 42.08 Quite Low
Chronic Disease 4 38.64 Quite Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, healthy individuals with the GCH1 haplotype experienced reduced GCH1 activation and lowered pain sensitivity.
Positive_regulation (activation) of GCH1 associated with pain and gch1
1) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 0.62 Pain Relevance 0.97
Recent studies show that transcriptional activation of GTP cyclohydrolase I (GCH1) in dorsal root ganglia (DRG) is significantly involved in the development and persistency of pain symptoms.
Positive_regulation (activation) of GTP cyclohydrolase in DRG associated with pain and gch1
2) Confidence 0.43 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785765 Disease Relevance 0.32 Pain Relevance 0.51
Recent studies show that transcriptional activation of GTP cyclohydrolase I (GCH1) in dorsal root ganglia (DRG) is significantly involved in the development and persistency of pain symptoms.
Positive_regulation (activation) of GCH1 in DRG associated with pain and gch1
3) Confidence 0.43 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785765 Disease Relevance 0.32 Pain Relevance 0.51
Delivery of rAAV-mediated shGCH1 into dorsal root ganglion (DRG)
Positive_regulation (mediated) of shGCH1 in DRG associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 0.66 Pain Relevance 0.35

General Comments

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