INT288515

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 9.26
Pain Relevance 10.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gch1) nucleolus (Gch1) nucleus (Gch1)
protein complex assembly (Gch1) protein complex (Gch1) cytoplasm (Gch1)
Anatomy Link Frequency
sciatic nerve 2
nerve 2
spinal cord 2
Gch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GCH1 728 100.00 Very High Very High Very High
Sciatic nerve 195 99.74 Very High Very High Very High
Neuropathic pain 182 99.64 Very High Very High Very High
Pain 598 99.56 Very High Very High Very High
Inflammation 130 97.56 Very High Very High Very High
dorsal root ganglion 208 97.36 Very High Very High Very High
Lasting pain 13 96.16 Very High Very High Very High
Spinal cord 78 95.48 Very High Very High Very High
algogenic 13 91.80 High High
Pain threshold 26 87.04 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 221 99.64 Very High Very High Very High
Pain 676 99.56 Very High Very High Very High
Nervous System Injury 169 98.08 Very High Very High Very High
INFLAMMATION 130 97.56 Very High Very High Very High
Ganglion Cysts 208 97.36 Very High Very High Very High
Toxicity 13 97.36 Very High Very High Very High
Neurodegenerative Disease 26 84.80 Quite High
Cytomegalovirus Infection 26 82.60 Quite High
Inborn Genetic Diseases 13 75.20 Quite High
Dystonia 13 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western-blotting analysis revealed that all specific siRNAs markedly inhibited rGCH1 expression, while control siRNAs did not.
Negative_regulation (inhibited) of Gene_expression (expression) of rGCH1
1) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 0.43 Pain Relevance 0.53
Decreased GCH1 expression was linked with the acquisition of pain resistance and decrease of microglial inflammation in the corresponding spinal cord.
Negative_regulation (Decreased) of Gene_expression (expression) of GCH1 in spinal cord associated with pain, inflammation, gch1 and spinal cord
2) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 1.23 Pain Relevance 1.36
We thus hypothesize that neuropathic pain may be attenuated by down-regulation of GCH1 expression, and propose a gene silencing system for this purpose.


Negative_regulation (down) of Gene_expression (expression) of GCH1 associated with gch1 and neuropathic pain
3) Confidence 0.40 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785765 Disease Relevance 0.35 Pain Relevance 0.60
These results collectively illustrate that rAAV-shGCH1 treatment of the sciatic nerve effectively suppresses GCH1 expression and leads to effective pain relief.
Negative_regulation (suppresses) of Gene_expression (expression) of GCH1 in sciatic nerve associated with pain, gch1 and sciatic nerve
4) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 0.84 Pain Relevance 1.14
In immunohistochemistry, shGCH1 introduction via rAAV2 significantly suppressed GCH1 expression to a similar level as the no-pain control group, while the up-regulation of GCH1 remained unchanged in the rAAV-GFP injected group (Fig. 6a), which supports previous report showing the positive association of pain symptoms with GCH1 activation [10].
Negative_regulation (suppressed) of Gene_expression (expression) of GCH1 associated with pain and gch1
5) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 0.76 Pain Relevance 1.10
Subsequently reduced GCH1 expression was evident from immunohistochemistry and western-blotting analysis.
Negative_regulation (reduced) of Gene_expression (expression) of GCH1 associated with gch1
6) Confidence 0.40 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785765 Disease Relevance 0.60 Pain Relevance 0.97
In our study, a single injection of the virus led to consistent down-regulation of GCH1 expression following pain surgery, and improved pain resistance over time.
Negative_regulation (down-regulation) of Gene_expression (expression) of GCH1 associated with pain and gch1
7) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 0.92 Pain Relevance 0.89
We thus hypothesize that neuropathic pain may be attenuated by down-regulation of GCH1 expression, and propose a gene silencing system for this purpose.


Negative_regulation (regulation) of Gene_expression (expression) of GCH1 associated with gch1 and neuropathic pain
8) Confidence 0.40 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2785765 Disease Relevance 0.35 Pain Relevance 0.60
Our data collectively suggest that rAAV-mediated shGCH1 synthesis effectively suppresses GCH1 expression.


Negative_regulation (suppresses) of Gene_expression (expression) of GCH1 associated with gch1
9) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 0.64 Pain Relevance 0.37
Attenuation of neuropathic pain behavior through downregulation of GCH1 levels via rAAV-shGCH1
Negative_regulation (downregulation) of Gene_expression (levels) of GCH1 associated with gch1 and neuropathic pain
10) Confidence 0.39 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 1.10 Pain Relevance 0.88
For knockdown of rGCH1 expression, nine siRNAs targeting various rGCH1 exon regions were designed (Fig. 1).
Negative_regulation (knockdown) of Gene_expression (expression) of rGCH1
11) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 0.44 Pain Relevance 0.61
Interestingly, we observed that shGCH1 introduction significantly reduced microglial activation, regardless of the time-point after nerve injury.
Negative_regulation (reduced) of Gene_expression (introduction) of shGCH1 in nerve associated with nervous system injury
12) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 0.99 Pain Relevance 1.00
Our data collectively suggest that rAAV-mediated shGCH1 synthesis effectively suppresses GCH1 expression.


Negative_regulation (suppresses) of Gene_expression (synthesis) of shGCH1 associated with gch1
13) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 0.63 Pain Relevance 0.36

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