INT288516

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.35
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gch1) nucleolus (Gch1) nucleus (Gch1)
protein complex assembly (Gch1) protein complex (Gch1) cytoplasm (Gch1)
Gch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GCH1 112 100.00 Very High Very High Very High
Potency 2 99.92 Very High Very High Very High
dorsal root ganglion 32 99.84 Very High Very High Very High
Neuropathic pain 28 97.76 Very High Very High Very High
Inflammation 20 96.52 Very High Very High Very High
Pain 92 93.00 High High
Sciatic nerve 30 91.44 High High
Dorsal horn 8 81.16 Quite High
Spinal cord 12 65.76 Quite High
Tetrahydrobiopterin 8 54.40 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 32 99.84 Very High Very High Very High
Neuropathic Pain 34 97.76 Very High Very High Very High
INFLAMMATION 20 96.52 Very High Very High Very High
Pain 104 93.00 High High
Nervous System Injury 26 75.68 Quite High
Inborn Genetic Diseases 2 44.88 Quite Low
Dystonia 2 41.28 Quite Low
Hypersensitivity 2 23.12 Low Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study provides clear evidence of the therapeutic potency of GCH1 down-regulation in DRG via rAAV-shGCH1-mediated silencing for treating neuropathic pain.
Negative_regulation (down) of Negative_regulation (regulation) of GCH1 associated with dorsal root ganglion, neuropathic pain, gch1 and potency
1) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 1.17 Pain Relevance 1.29
The present study provides clear evidence of the therapeutic potency of GCH1 down-regulation in DRG via rAAV-shGCH1-mediated silencing for treating neuropathic pain.
Negative_regulation (regulation) of Negative_regulation (down) of GCH1 associated with dorsal root ganglion, neuropathic pain, gch1 and potency
2) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785765 Disease Relevance 1.17 Pain Relevance 1.29

General Comments

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