INT28852

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Context Info
Confidence 0.42
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 4.23
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
medial 1
brain 1
frontal areas 1
OFC 1
OFC 1
OFC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 6 100.00 Very High Very High Very High
Lasting pain 5 99.58 Very High Very High Very High
opiate 5 99.52 Very High Very High Very High
imagery 11 99.50 Very High Very High Very High
depression 56 99.44 Very High Very High Very High
Pain 15 99.38 Very High Very High Very High
Acupuncture 2 98.56 Very High Very High Very High
Nucleus accumbens 16 98.52 Very High Very High Very High
amygdala 24 98.08 Very High Very High Very High
withdrawal 12 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 13 100.00 Very High Very High Very High
Pain 16 99.58 Very High Very High Very High
Depression 72 99.44 Very High Very High Very High
Aggression 62 97.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 12 89.96 High High
INFLAMMATION 3 89.12 High High
Anxiety Disorder 50 87.84 High High
Manic Depressive Disorder 8 83.12 Quite High
Reprotox - General 3 25 76.00 Quite High
Cognitive Disorder 23 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peroxynitrite-induced luminol (54+/-7%, n=7, tetracaine, and 26+/-5%, n=8, bupivacaine, at 1 mM) and lucigenin CL (58+/-3%, n=6, tetracaine, and 22+/-14%, n=9, bupivacaine, at 1 mM) were markedly inhibited.
Negative_regulation (inhibited) of lucigenin CL
1) Confidence 0.42 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12757744 Disease Relevance 0 Pain Relevance 0.20
In addition, we measured the neurochemical content of the OFC, amygdala and nucleus accumbens using HPLC, and found that in prolonged chronic pain animals there was a decrease in the tonic levels of dopamine, DOPAC (3,4-hydroxyphenyl-acetic acid) and 5-HIAA (5-hydroxyindole-3-acetic acid) in the OFC.
Negative_regulation (decrease) of OFC in OFC associated with nucleus accumbens, dopamine, lasting pain and amygdala
2) Confidence 0.38 Published 2009 Journal Neuroscience Section Abstract Doc Link 19362121 Disease Relevance 0.78 Pain Relevance 0.81
The authors studied the effect of electric acupuncture stimulation (EAP) on the changes in pain thresholds prior to and after removal of the orbito-frontal cortex (OFC) of the brain in behavioral experiments on adult cats.
Negative_regulation (removal) of OFC in brain associated with pain, urological neuroanatomy and acupuncture
3) Confidence 0.37 Published 1989 Journal Biull Eksp Biol Med Section Abstract Doc Link 2804287 Disease Relevance 0.71 Pain Relevance 0.54
Removal of OFC increased the thresholds of pain response at the 4th and the 5th levels of the conventional scale, reflecting emotionally-affective manifestations of pain, and intensified the effect of antinociceptive EAP.
Negative_regulation (Removal) of OFC in OFC associated with pain, urological neuroanatomy and antinociceptive
4) Confidence 0.37 Published 1989 Journal Biull Eksp Biol Med Section Abstract Doc Link 2804287 Disease Relevance 0.73 Pain Relevance 0.56
The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period.
Negative_regulation (decreased) of OFC associated with opiate, withdrawal and imagery
5) Confidence 0.37 Published 2006 Journal Neuroscience Section Abstract Doc Link 16377092 Disease Relevance 0 Pain Relevance 0.83
In contrast, inactivation of the OFC did impair reversal learning; yet, these rats ceased using the previously acquired response rule as readily as controls.
Negative_regulation (inactivation) of OFC
6) Confidence 0.34 Published 2008 Journal Neurobiol Learn Mem Section Abstract Doc Link 18054257 Disease Relevance 0 Pain Relevance 0.09
We used a tilted acquisition sequence at 30 ° to the AC-PC line to recover signal loss from dropout in the medial OFC [

53].

Negative_regulation (loss) of OFC in medial
7) Confidence 0.34 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1484497 Disease Relevance 0 Pain Relevance 0.09
Neuroimaging studies of manic patients have shown that in direct contrast to depression, resting state activity is decreased in the OFC [249,250] and increased in dorsal frontal areas during manic episodes [250,251].
Negative_regulation (decreased) of OFC in frontal areas associated with depression
8) Confidence 0.28 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 1.09 Pain Relevance 0.12
Although the relationship between changes in social interaction and decision-making after ACC lesions is unclear, OFC impairments in emotionality were correlated with increased impulsive choice.



Negative_regulation (impairments) of OFC
9) Confidence 0.12 Published 2007 Journal The European Journal of Neuroscience Section Abstract Doc Link PMC2228395 Disease Relevance 0.21 Pain Relevance 0
In a recent study, Ross and colleagues showed that rats with cholinergic depletions of the OFC were impaired in acquiring social transmission of food preference (STFP; Ross et al., 2005).
Negative_regulation (depletions) of OFC
10) Confidence 0.12 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2228395 Disease Relevance 0.70 Pain Relevance 0
L-arginine also significantly decreased CL-RI and increased serum progesterone concentrations between the treatment cycle and the previous cycle (Table 1).


Negative_regulation (decreased) of CL-RI
11) Confidence 0.02 Published 2009 Journal J Ovarian Res Section Body Doc Link PMC2633338 Disease Relevance 0 Pain Relevance 0
Vitamin E significantly decreased CL-RI and increased serum progesterone concentrations between the treatment cycle and the previous cycle (Table 1).


Negative_regulation (decreased) of CL-RI
12) Confidence 0.02 Published 2009 Journal J Ovarian Res Section Body Doc Link PMC2633338 Disease Relevance 0 Pain Relevance 0

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