INT288540

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Context Info
Confidence 0.53
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.12
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 30 92.52 High High
Kinase C 5 84.16 Quite High
Eae 67 63.88 Quite High
Hippocampus 17 60.92 Quite High
Dopamine 10 48.32 Quite Low
depression 15 44.72 Quite Low
antidepressant 8 43.36 Quite Low
monoamine 12 5.00 Very Low Very Low Very Low
long-term potentiation 10 5.00 Very Low Very Low Very Low
tail-flick 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aggression 26 100.00 Very High Very High Very High
Targeted Disruption 111 99.84 Very High Very High Very High
Stress 37 92.04 High High
Attention Deficit Hyperactivity Disorder 20 75.12 Quite High
Manic Depressive Disorder 18 74.56 Quite High
Cognitive Disorder 19 70.96 Quite High
Schizophrenia 7 61.84 Quite High
Congenital Anomalies 10 50.00 Quite Low
Depression 17 44.72 Quite Low
Anxiety Disorder 58 28.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased social interaction and aggression in GSK-3?
Negative_regulation (Decreased) of GSK-3 Binding (interaction) of associated with aggression
1) Confidence 0.53 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.58 Pain Relevance 0.30
has been reported to be involved in the PI3K/Akt pathway [25] and phosphorylated Akt inhibits the activity of GSK3?
Negative_regulation (inhibits) of GSK3 Binding (activity) of
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956634 Disease Relevance 1.04 Pain Relevance 0.07
The mechanism underlying decreased social behavior in GSK-3?
Negative_regulation (decreased) of GSK-3 Binding (behavior) of
3) Confidence 0.34 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.50 Pain Relevance 0.06
Furthermore, to detect physical association between BMAL1 and GSK3?
Negative_regulation (detect) of GSK3 Binding (association) of
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0

General Comments

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