INT288596

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (CAV1, Kcnma1) plasma membrane (CAV1, Kcnma1) endosome (CAV1)
transport (Kcnma1) mitochondrion (CAV1) small molecule metabolic process (CAV1)
CAV1 (Homo sapiens)
Kcnma1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 4 25.00 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 97.10 Very High Very High Very High
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, mutation of all three aromatic amino acids (mutant Y1007A, F1012A, Y1015A) was necessary to disrupt the association between caveolin and the maxi-K channel, as visualized by immunofluorescence and immunoprecipitation.


Positive_regulation (necessary) of caveolin Binding (association) of maxi-K channel
1) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
We stress that, in spite of the differences between the two studies, they do agree on the localization and amino acid sequence of the consensus site that mediates binding of the maxi-K channel to caveolin [8].
Positive_regulation (mediates) of caveolin Binding (binding) of maxi-K channel associated with stress
2) Confidence 0.01 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0.10 Pain Relevance 0

General Comments

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