INT2886

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1977
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 4.55
Pain Relevance 3.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SCT) cellular_component (SCT)
Anatomy Link Frequency
superior 4
pancreas 1
acinar cells 1
pancreatic duct 1
Parathyroid 1
SCT (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 43 100.00 Very High Very High Very High
Cholecystokinin 11 100.00 Very High Very High Very High
dexamethasone 1925 97.82 Very High Very High Very High
Somatostatin 14 93.44 High High
Bile 16 93.40 High High
chemokine 33 93.04 High High
fibrosis 1 93.00 High High
pregabalin 1 89.76 High High
Chronic pancreatitis 10 89.44 High High
Inflammation 7 83.72 Quite High
Disease Link Frequency Relevance Heat
Adhesions 108 100.00 Very High Very High Very High
Exocrine Pancreatic Insufficiency 2 98.82 Very High Very High Very High
Disease 300 96.92 Very High Very High Very High
Autism 44 94.00 High High
Fibrosis 1 93.00 High High
Nicotine Addiction 49 89.88 High High
Recurrence 45 89.44 High High
Pancreatitis 10 89.44 High High
INFLAMMATION 9 83.72 Quite High
Pancreatic Cancer 73 80.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The duodenal mucosa in chronic pancreas patients with pancreatic insufficiency has a normal concentration of s-cells and, therefore, the production of secretin is preserved.
Gene_expression (production) of secretin in pancreas associated with exocrine pancreatic insufficiency
1) Confidence 0.78 Published 2005 Journal JOP Section Abstract Doc Link 15767727 Disease Relevance 0.72 Pain Relevance 0.28
John's Wort extract, synthetic human secretin; Taxus, telavancin hydrochloride, telithromycin, temoporfin, tenofovir disoproxil fumarate, tenofovir disoproxil fumarate/emtricitabine, teriparatide, testosterone gel, TG-1024, tirapazamine, travoprost, travoprost/timolol; Valdecoxib, valganciclovir hydrochloride, voriconazole; Ximelagatran.
Gene_expression (synthetic) of secretin
2) Confidence 0.65 Published 2005 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 15834452 Disease Relevance 0.21 Pain Relevance 0.31
Cats were given a commercially available secretin product (ChiRho Stim) while the pancreatic duct was monitored sonographically.
Gene_expression (product) of secretin in pancreatic duct
3) Confidence 0.65 Published 2010 Journal Vet Radiol Ultrasound Section Abstract Doc Link 20166401 Disease Relevance 0.18 Pain Relevance 0.20
Unis et al. [16] in a randomized double-blind, placebo-controlled study, reported no evidence that either biologic or synthetic secretin provided amelioration of symptoms beyond placebo.
Gene_expression (synthetic) of secretin
4) Confidence 0.57 Published 2005 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC1308834 Disease Relevance 0.52 Pain Relevance 0
The Secretin family (8 members)
Gene_expression (family) of Secretin
5) Confidence 0.42 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0.27
No significant crossreaction was found with gastrin, motilin, vasoactive polypeptide (VIP), gastric inhibitory polypeptide (GIP), natural and synthetic secretin, pancreatic glucagon or insulin.
Gene_expression (synthetic) of secretin
6) Confidence 0.35 Published 1977 Journal Clin. Chim. Acta Section Abstract Doc Link 562241 Disease Relevance 0.07 Pain Relevance 0.79
It is also notable that several GPCRs known to participate in pancreatic functions are missing, such as cholecystokinin receptor A and B, gastric-inhibitory peptide receptor and the secretin receptor (Additional file 4, table S2).
Gene_expression (missing) of secretin associated with cholecystokinin
7) Confidence 0.22 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2246102 Disease Relevance 0 Pain Relevance 0.10
The Secretin family can be divided into five main branches a) Corticotrophin Releasing Factor (CRF); b) Secretin (SCT), Vasoactive Intestinal Peptide (VIP), Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Growth Hormone Releasing Hormone (GHRH); c) Glucagon (GCG), Glucagon-Like Peptide (GLP), Glucose Insulinotropic Peptide (GIP); d) Parathyroid Hormone (PTH) and e) Calcitonin (CAL) and Calcitonin Gene-Related Peptide (CGRP) [21,22] of which groups a, d and e are found in amphioxus (see Additional file 1, figure S5).
Gene_expression (found) of Secretin in Parathyroid
8) Confidence 0.22 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2246102 Disease Relevance 0.09 Pain Relevance 0
The chicken GPCR dataset was divided into Adhesion, Frizzled, Glutamate, Secretin, Rhodopsin, and Taste 2 families based on the human dataset.
Gene_expression (families) of Secretin associated with glutamate and adhesions
9) Confidence 0.21 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1472694 Disease Relevance 0.10 Pain Relevance 0.05
Pancreatic secretion is under hormonal control mainly by cholecystokinin which stimulates enzyme production and secretion from acinar cells and by secretin which induces bicarbonate secretion from ductal cells [24].
Gene_expression (production) of secretin in acinar cells associated with cholecystokinin
10) Confidence 0.19 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2613155 Disease Relevance 0.82 Pain Relevance 0.05
Drosophila 5HTA receptor (5HTA_Dro) of family A was used as out-group for secretin, glutamate, cell adhesion and frizzled receptors.
Gene_expression (receptors) of secretin associated with glutamate and adhesions
11) Confidence 0.10 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1192796 Disease Relevance 0.10 Pain Relevance 0.10
In 1991, Nagata's group reported the expression cloning of the receptor for the gut hormone secretin [6].
Gene_expression (expression) of secretin in gut
12) Confidence 0.08 Published 2001 Journal Genome Biol Section Body Doc Link PMC138994 Disease Relevance 0 Pain Relevance 0.07
In particular, lenalidomide plus dexamethasone is effective at prolonging TTP independently of patient age, number or type of previous therapies including previous autologous SCT, and ?
Gene_expression (previous) of SCT associated with dexamethasone
13) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899783 Disease Relevance 0.25 Pain Relevance 0.18
Interim data suggest there is no survival advantage of tandem over single autologous SCT, with the latter also being preferred over allogeneic SCT due to its superior efficacy in the absence of a syngeneic donor, its safety, and the absence of biological age-related disease differences.34 However, preliminary results for nonmyeloablative allogeneic transplantation are encouraging and support the feasibility of this approach.34 As almost all patients relapse, maintenance treatments that help prolong the duration of remission and survival are used, including thalidomide.35–37
Gene_expression (preferred) of SCT in superior associated with disease and recurrence
14) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899783 Disease Relevance 0.37 Pain Relevance 0.29
Interim data suggest there is no survival advantage of tandem over single autologous SCT, with the latter also being preferred over allogeneic SCT due to its superior efficacy in the absence of a syngeneic donor, its safety, and the absence of biological age-related disease differences.34 However, preliminary results for nonmyeloablative allogeneic transplantation are encouraging and support the feasibility of this approach.34 As almost all patients relapse, maintenance treatments that help prolong the duration of remission and survival are used, including thalidomide.35–37
Gene_expression (preferred) of SCT in superior associated with disease and recurrence
15) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899783 Disease Relevance 0.37 Pain Relevance 0.30
Interim data suggest there is no survival advantage of tandem over single autologous SCT, with the latter also being preferred over allogeneic SCT due to its superior efficacy in the absence of a syngeneic donor, its safety, and the absence of biological age-related disease differences.34 However, preliminary results for nonmyeloablative allogeneic transplantation are encouraging and support the feasibility of this approach.34 As almost all patients relapse, maintenance treatments that help prolong the duration of remission and survival are used, including thalidomide.35–37
Gene_expression (due) of SCT in superior associated with disease and recurrence
16) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899783 Disease Relevance 0.37 Pain Relevance 0.30
Interim data suggest there is no survival advantage of tandem over single autologous SCT, with the latter also being preferred over allogeneic SCT due to its superior efficacy in the absence of a syngeneic donor, its safety, and the absence of biological age-related disease differences.34 However, preliminary results for nonmyeloablative allogeneic transplantation are encouraging and support the feasibility of this approach.34 As almost all patients relapse, maintenance treatments that help prolong the duration of remission and survival are used, including thalidomide.35–37
Neg (absence) Gene_expression (absence) of SCT in superior associated with disease and recurrence
17) Confidence 0.04 Published 2010 Journal Core evidence Section Body Doc Link PMC2899783 Disease Relevance 0.37 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox