INT28861

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Context Info
Confidence 0.46
First Reported 1986
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 61
Total Number 62
Disease Relevance 25.61
Pain Relevance 6.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh) signal transduction (Gh) mitochondrion (Gh)
extracellular space (Gh) extracellular region (Gh) plasma membrane (Gh)
Anatomy Link Frequency
blood 2
bile duct 2
plasma 1
thoracic 1
joint 1
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 110 100.00 Very High Very High Very High
Clonidine 24 99.76 Very High Very High Very High
Pain 18 99.28 Very High Very High Very High
antagonist 134 99.00 Very High Very High Very High
cva 9 97.84 Very High Very High Very High
Somatostatin 538 97.60 Very High Very High Very High
headache 27 96.80 Very High Very High Very High
Inflammation 97 96.16 Very High Very High Very High
opiate 8 94.28 High High
narcan 6 94.00 High High
Disease Link Frequency Relevance Heat
Growth Hormone Deficiency 21 100.00 Very High Very High Very High
Lipodystrophy 7 100.00 Very High Very High Very High
Prolactinoma 5 99.98 Very High Very High Very High
Panniculitis 4 99.98 Very High Very High Very High
Acromegaly 522 99.92 Very High Very High Very High
Syndrome 345 99.92 Very High Very High Very High
Cerebrovascular Disease 16 99.92 Very High Very High Very High
Aging 387 99.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 99.68 Very High Very High Very High
Hepatitis 3 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although transient urinary retention associated with GH is not uncommon, chronic neuropathic pain has not been reported previously.
GH Binding (associated) of
1) Confidence 0.46 Published 2004 Journal Acta Obstet Gynecol Scand Section Body Doc Link 15453891 Disease Relevance 0.31 Pain Relevance 0
[Growth hormone and its interactions with chosen parameters of hormonal state in pre-menopausal women after mastectomy for breast cancer on adjuvant chemotherapy].
Growth hormone Binding (interactions) of associated with endometriosis (extended) and breast cancer
2) Confidence 0.43 Published 2000 Journal Wiad. Lek. Section Title Doc Link 10983383 Disease Relevance 0.59 Pain Relevance 0.11
CMF did not influence the interactions between GH and other studied parameters.
GH Neg (not) Binding (interactions) of
3) Confidence 0.43 Published 2000 Journal Wiad. Lek. Section Abstract Doc Link 10983383 Disease Relevance 0.53 Pain Relevance 0.13
It is therefore concluded that serial GH sampling to 90 min is the preferred duration when screening for GH deficiency with clonidine.
GH Binding (deficiency) of associated with clonidine
4) Confidence 0.36 Published 2001 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 11795657 Disease Relevance 0 Pain Relevance 0.36
METHODS: We present two immunocompetent patients with GH associated with neuropathic symptoms.
GH Binding (associated) of
5) Confidence 0.34 Published 2004 Journal Acta Obstet Gynecol Scand Section Body Doc Link 15453891 Disease Relevance 0.38 Pain Relevance 0
From the data presented above and despite limitations in design, it would appear that lanreotide AutogelĀ® and octreotide LAR are equipotent in normalizing GH and IGF-I concentrations.
GH Binding (normalizing) of
6) Confidence 0.33 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0 Pain Relevance 0.04
Normal GH, defined as a concentration below 2.5 ?
GH Binding (concentration) of
7) Confidence 0.33 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0 Pain Relevance 0
Discrepancies between studies may be explained by a single GH or IGF-I measurement being used in most studies, which is hardly representative for disease status in the entire follow-up period; by the unavailability of IGF-I in a substantial number of patients; and by GH and IGF-I assay differences.
GH Binding (single) of associated with disease
8) Confidence 0.33 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.45 Pain Relevance 0.07
Most studies have suggested that a lower GH, for example below 2.5 ?
GH Binding (example) of
9) Confidence 0.33 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721386 Disease Relevance 0.52 Pain Relevance 0.08
Prolactinoma associated with transient growth hormone deficiency but persistent growth retardation.
growth hormone Binding (associated) of associated with prolactinoma and growth hormone deficiency
10) Confidence 0.33 Published 1994 Journal J Pediatr Endocrinol Section Title Doc Link 8186829 Disease Relevance 0.54 Pain Relevance 0.14
Results indicated that in cultures supplemented (48 h) with either TGF-beta, TGF-beta + IGF-1 or with GH, an increased height and area of TB-positive staining as well as increased incorporation of (35)S-SO(4) into sulfated PG were observed.
GH Binding (supplemented) of
11) Confidence 0.32 Published 2000 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 10971036 Disease Relevance 0.20 Pain Relevance 0.18
IMPLICATIONS FOR PRACTICE: There is now clinical evidence indicating that recommending GS, GH, and CS for the treatment of mild knee pain from OA is ineffective.
GH Binding (recommending) of in knee
12) Confidence 0.31 Published 2006 Journal J Am Acad Nurse Pract Section Body Doc Link 16999714 Disease Relevance 0.07 Pain Relevance 0
GH has been shown to be associated with joint symptoms such as pain and swelling.
GH Binding (associated) of in joint associated with pain and pressure and volume under development
13) Confidence 0.30 Published 2005 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 16173241 Disease Relevance 0.27 Pain Relevance 0.17
The receptor lacks intrinsic kinase activity, but GH binding to its extracellular domain induces the recruitment and activation of the tyrosine kinase, Janus kinase 2 (JAK2).
GH Binding (binding) of
14) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.11 Pain Relevance 0.08
Binding of GH to the extracellular domains of the receptor dimer causes a relative shift and rotation of the subunits (Brown et al 2005).
GH Binding (Binding) of
15) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0 Pain Relevance 0
Growth hormone, both the 20 kDa and the 22 kDa isoforms, amplify GHR and GHBP gene transcription in human mesangial cells in vitro and this effect was blocked specifically by pegvisomant (Meinhardt et al 2003).
Growth hormone Binding (amplify) of in mesangial cells
16) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.49 Pain Relevance 0
However, binding affinity to the cell surface receptor is equivalent between B2036 and GH (Ross et al 2001).
GH Binding (affinity) of
17) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.07 Pain Relevance 0.03
More than 40 different mutations in the human have been described, but mutations of the intracellular domain, preventing activation but not GH binding, are rare (Rosenbloom 2000).
GH Binding (binding) of
18) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.24 Pain Relevance 0.03
Mutations of the extracellular domain of the receptor prevent GH binding and lead to the so called Laron syndrome, characterized by severely stunted growth, GH insensitivity, and increased serum GH concentration (Laron et al 1966).
GH Binding (binding) of associated with laron syndrome
19) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.18 Pain Relevance 0
X-ray crystallography studies of the GH-GH-receptor complex and of GH with the extracellular domain of the receptor have demonstrated that each GH molecule is bound by two receptor molecules, suggesting dimerization of the receptor (Figure 3).
GH Binding (bound) of
20) Confidence 0.28 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0 Pain Relevance 0.04

General Comments

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