INT28863

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Context Info
Confidence 0.04
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.87
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dhfr) mRNA binding (Dhfr) methyltransferase activity (Mtr)
intracellular (Mtr) cytoplasm (Mtr)
Mtr (Rattus norvegicus)
Dhfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methotrexate 14 100.00 Very High Very High Very High
anesthesia 1 89.32 High High
depression 1 57.36 Quite High
Disease Link Frequency Relevance Heat
Cancer 1 92.68 High High
Breast Cancer 1 91.88 High High
Toxicity 5 90.40 High High
Body Weight 1 70.48 Quite High
Diarrhoea 1 65.60 Quite High
Weight Loss 1 64.56 Quite High
Depression 1 57.36 Quite High
Leukopenia 1 56.08 Quite High
Thrombocytopenia 1 54.56 Quite High
Death 1 32.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This phenomenon may be attributed to the synergistic effects of nitrous oxide, which inactivates the cobalamin coenzyme of methionine synthase, and MTX, which inhibits dihydrofolate reductase, on folate metabolism.
methionine synthase Negative_regulation (inhibits) of dihydrofolate reductase associated with methotrexate
1) Confidence 0.04 Published 1989 Journal Cancer Res. Section Abstract Doc Link 2804978 Disease Relevance 0.87 Pain Relevance 0.45

General Comments

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