INT288630

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.99
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cntf) cytosol (Cntf) extracellular space (Cntf)
growth (Cntf) nucleus (Cntf) cytoplasm (Cntf)
Anatomy Link Frequency
ciliary 2
spinal 1
retina 1
Cntf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 117 99.98 Very High Very High Very High
rheumatoid arthritis 82 98.88 Very High Very High Very High
antagonist 3 95.68 Very High Very High Very High
Inflammatory response 24 81.08 Quite High
neurotrophin 3 2 77.36 Quite High
Nerve growth factor 2 68.80 Quite High
Central nervous system 5 57.12 Quite High
intrathecal 7 56.16 Quite High
Inflammation 32 53.40 Quite High
Arthritis 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Leukemia 4 100.00 Very High Very High Very High
Motor Neuron Diseases 198 99.18 Very High Very High Very High
Disease 104 99.04 Very High Very High Very High
Rheumatoid Arthritis 84 98.88 Very High Very High Very High
Nervous System Injury 3 90.62 High High
Apoptosis 51 85.36 High High
Death 32 83.60 Quite High
Anaemia 3 82.04 Quite High
Fever 2 81.64 Quite High
INFLAMMATION 56 80.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a further example, in the presence of ciliary neurotrophic factor (CNTF), which is produced by the developing retina, higher numbers of P0 RPCs can be driven to express opsin [12].
Gene_expression (produced) of CNTF in retina
1) Confidence 0.75 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0.06 Pain Relevance 0
After time in culture, P0 RPCs not expressing opsin and exposed to CNTF tend to differentiate toward a bipolar cell fate [14].
Gene_expression (exposed) of CNTF
2) Confidence 0.65 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0.06 Pain Relevance 0
IL-6 family cytokines consist of IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CP-1).
Gene_expression (consist) of CNTF in ciliary associated with leukemia and cytokine
3) Confidence 0.65 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.28 Pain Relevance 0.81
Our analysis revealed no significant difference in the expression of Lifr, a receptor for LIF and a co-receptor for CNTF, or Cntfr, the primary receptor for CNTF.
Gene_expression (expression) of CNTF
4) Confidence 0.58 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.23 Pain Relevance 0.10
Our analysis revealed no significant difference in the expression of Lifr, a receptor for LIF and a co-receptor for CNTF, or Cntfr, the primary receptor for CNTF.
Gene_expression (expression) of CNTF
5) Confidence 0.58 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.23 Pain Relevance 0.10
Ciliary neurotrophic factor (CNTF) is a neuroactive cytokine found in Schwann cells, which seems to be released in response to nerve injury.23 CNTF maintains survival of adult motor neurons and mice lacking the CNTF gene develop mild, progressive motor neuron loss.48 In a recent study, serum level of CNTF was significantly higher in ALS patients than in controls.49 There was no difference between familial and sporadic ALS, and a trend for higher levels was observed in patients with spinal-onset ALS, compared to patients with a bulbar onset of the disease.49 ALS patients in two trials (n = 1,300) were treated with subcutaneous CNTF.50,51 No significant difference in either primary or secondary outcomes was observed between CNTF and placebo groups.50–52 However, a significant increase of the incidence of several adverse events was noted in groups treated with higher doses of CNTF.52 Therefore CNTF can not be considered beneficial for patients with ALS.


Neg (No) Gene_expression (treated) of CNTF in spinal associated with nervous system injury, disease, motor neuron diseases and cytokine
6) Confidence 0.42 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785861 Disease Relevance 0.90 Pain Relevance 0.10
IL-6 family cytokines consist of IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CP-1).
Gene_expression (consist) of ciliary neurotrophic factor in ciliary associated with leukemia and cytokine
7) Confidence 0.30 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.23 Pain Relevance 0.78

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