INT28865

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Context Info
Confidence 0.57
First Reported 1980
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 15.03
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
visceral 6
CeA 4
lymph nodes 2
hypothalamus 2
epithelium 2
Cea (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 16 100.00 Very High Very High Very High
agonist 2 99.68 Very High Very High Very High
Cannabinoid 11 99.52 Very High Very High Very High
qutenza 6 99.42 Very High Very High Very High
abdominal pain 3 98.68 Very High Very High Very High
pain pelvic 1 98.24 Very High Very High Very High
unmyelinated 2 95.28 Very High Very High Very High
c fibre 2 94.24 High High
Endocannabinoid 2 90.96 High High
Cannabinoid receptor 1 84.88 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 12 100.00 Very High Very High Very High
Cyst 18 99.98 Very High Very High Very High
Food Hypersensitivity 6 99.98 Very High Very High Very High
Hypoalbuminemia 3 99.96 Very High Very High Very High
Intestinal Cancer 4 99.88 Very High Very High Very High
Hypersensitivity 9 99.72 Very High Very High Very High
Colon Cancer 82 99.70 Very High Very High Very High
Hepatomegaly 1 99.68 Very High Very High Very High
Metastasis 221 99.62 Very High Very High Very High
Ovarian Cancer 3 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, enhanced expression of CEA may confer on cancer cells the ability to invade adjacent tissues and to metastasize to lymph nodes or distant organs.
Positive_regulation (enhanced) of Gene_expression (expression) of CEA in lymph nodes associated with cancer
1) Confidence 0.57 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782159 Disease Relevance 1.16 Pain Relevance 0
When transgenic mice that express the human carcinoembryonic antigen (CEA) gene (CEA transgenic) were bred with mice bearing a mutation in the Apc(Delta850) gene (multiple intestinal neoplasia mice), the progeny (CEA transgenic/multiple intestinal neoplasia) spontaneously develop multiple intestinal neoplasms that overexpress CEA and COX-2.
Positive_regulation (overexpress) of Gene_expression (overexpress) of CEA associated with targeted disruption and intestinal cancer
2) Confidence 0.49 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15150127 Disease Relevance 1.31 Pain Relevance 0.05
This is the first case reported in the literature of a true benign splenic cyst producing high levels of CEA and CA 19-9 in serum and cystic fluid.
Positive_regulation (levels) of Gene_expression (producing) of CEA associated with cyst
3) Confidence 0.46 Published 1998 Journal Am Surg Section Abstract Doc Link 9843333 Disease Relevance 0.62 Pain Relevance 0.07
In this series of studies we show that after oral or nasal ovalbumin (OVA) challenge, allergic mice present increased Fos expression in the paraventricular nucleus of the hypothalamus (PVN) and in the central nucleus of the amygdala (CeA).
Positive_regulation (increased) of Gene_expression (expression) of CeA in hypothalamus associated with hypersensitivity and amygdala
4) Confidence 0.45 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17192560 Disease Relevance 0.64 Pain Relevance 0.22
However, capsaicin did not modify food allergy-induced c-fos expression in the CeA.
Positive_regulation (induced) of Gene_expression (expression) of CeA in CeA associated with food hypersensitivity, qutenza and amygdala
5) Confidence 0.44 Published 2004 Journal Brain Res. Section Abstract Doc Link 15120595 Disease Relevance 0.51 Pain Relevance 0.73
CONCLUSION: rSO(2) is reliably improved during carotid cross-clamping by increasing Fio(2) in patients undergoing CEA with general anesthesia.
Positive_regulation (increasing) of Gene_expression (undergoing) of CEA
6) Confidence 0.43 Published 2010 Journal Anesth. Analg. Section Body Doc Link 19955500 Disease Relevance 0 Pain Relevance 0
However, the combination of restraint and CB1 agonist administration produced robust Fos induction within the CeA, indicating a synergistic interaction between environmental stress and CB1 receptor activation.
Positive_regulation (induction) of Gene_expression (produced) of CeA in CeA associated with stress, cannabinoid, agonist and amygdala
7) Confidence 0.38 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15280883 Disease Relevance 0.54 Pain Relevance 0.86
Tumor stage is the most important predictor of survival in colorectal cancer (5, 6), and s-CEA levels tended to increase progressively with the stage of disease (3).
Positive_regulation (increase) of Gene_expression (levels) of CEA associated with cancer, colon cancer and disease
8) Confidence 0.36 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782159 Disease Relevance 1.20 Pain Relevance 0
Reoperation was indicated by elevated CEA levels in seven patients (70 percent), persistent pelvic pain in six (60 percent), and a suspicious radiologic study in seven (70 percent).
Positive_regulation (elevated) of Gene_expression (levels) of CEA associated with pain pelvic
9) Confidence 0.35 Published 1989 Journal Dis. Colon Rectum Section Abstract Doc Link 2806020 Disease Relevance 0.49 Pain Relevance 0.10
As CEA is the potent marker for lung adenocarcinoma and EGFR is specially expressed in glioblastoma multiforme, we also performed immunohistochemistrical staining to examine the expression of CEA and EGFR in xenografts derived from metastatic adenocarcinoma or glioblastoma multiforme.


Spec (examine) Positive_regulation (examine) of Spec (examine) Gene_expression (expression) of CEA in lung associated with adenocarcinoma and glioblastoma
10) Confidence 0.35 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2907866 Disease Relevance 1.14 Pain Relevance 0
In breast cancer there is often overexpression of the breast cancer antigen CA15-3, the carcinoembryonic antigen (CEA) and the ovarian cancer antigen CA125, which makes them potential target antigens for immunotherapy.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CEA associated with ovarian cancer and breast cancer
11) Confidence 0.33 Published 2000 Journal Cancer Biother. Radiopharm. Section Abstract Doc Link 11155821 Disease Relevance 0.83 Pain Relevance 0
In the univariate analyses for survival, significant prognostic factors were visceral metastases, hypoalbuminemia, elevated lactate dehydrogenase levels, elevated AP levels, PS, and elevated CEA and CA 19-9 levels.
Positive_regulation (elevated) of Gene_expression (levels) of CEA in visceral associated with hypoalbuminemia and metastasis
12) Confidence 0.32 Published 2003 Journal Clin Colorectal Cancer Section Abstract Doc Link 12620142 Disease Relevance 0.62 Pain Relevance 0.06
In the univariate analyses for survival, significant prognostic factors were visceral metastases, hypoalbuminemia, elevated lactate dehydrogenase levels, elevated AP levels, PS, and elevated CEA and CA 19-9 levels.
Positive_regulation (elevated) of Gene_expression (levels) of CEA in visceral associated with hypoalbuminemia and metastasis
13) Confidence 0.32 Published 2003 Journal Clin Colorectal Cancer Section Abstract Doc Link 12620142 Disease Relevance 0.55 Pain Relevance 0.06
In the univariate analyses, factors predictive of time to progression were visceral metastases, elevated alkaline phosphatase (AP) levels, performance status (PS), and elevated carcinoembryonic antigen (CEA) and CA 19-9 levels.
Positive_regulation (elevated) of Gene_expression (levels) of CEA in visceral associated with metastasis
14) Confidence 0.32 Published 2003 Journal Clin Colorectal Cancer Section Abstract Doc Link 12620142 Disease Relevance 0.76 Pain Relevance 0.07
We also prospectively investigated whether a rise in CA 15-3 or CEA levels during the course of therapy could predict secondary progression in patients who had previously experienced CB (PR or SD ?
Positive_regulation (rise) of Gene_expression (levels) of CEA associated with disease
15) Confidence 0.27 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1435763 Disease Relevance 0.87 Pain Relevance 0.04
Serum levels of CEA and serum and urine levels of beta-HCG were markedly elevated.
Positive_regulation (elevated) of Gene_expression (levels) of CEA in urine
16) Confidence 0.21 Published 1980 Journal Am. J. Gastroenterol. Section Abstract Doc Link 6990747 Disease Relevance 0.46 Pain Relevance 0.10
The colonic epithelium also expressed carcinoembryonic antigen (CEA) but there was no CEA expression in the renal glomeruli.


Neg (no) Positive_regulation (was) of Neg (no) Gene_expression (expression) of CEA in epithelium
17) Confidence 0.19 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1852400 Disease Relevance 0.26 Pain Relevance 0
Elevated serum CEA levels of more than 3.0ng/ml were decreased in 7/8 patients (87.5%).
Positive_regulation (Elevated) of Gene_expression (levels) of CEA
18) Confidence 0.16 Published 1988 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 2831818 Disease Relevance 0.91 Pain Relevance 0.09
Twenty patients from Group 2 had elevated CEA levels prior to SIRT and 1 patient had a normal CEA level.
Positive_regulation (elevated) of Gene_expression (levels) of CEA
19) Confidence 0.11 Published 2005 Journal BMC Nucl Med Section Body Doc Link PMC1360059 Disease Relevance 0.29 Pain Relevance 0
Her serum CEA level was elevated at 11.1 ?
Positive_regulation (elevated) of Gene_expression (level) of CEA
20) Confidence 0.09 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2542374 Disease Relevance 0.74 Pain Relevance 0

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